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Fiber enhanced Raman spectroscopic analysis as a novel method for diagnosis and monitoring of diseases related to hyperbilirubinemia and hyperbiliverdinemia

Fiber enhanced resonance Raman spectroscopy (FERS) is introduced for chemically selective and ultrasensitive analysis of the biomolecules hematin, hemoglobin, biliverdin, and bilirubin. The abilities for...

Indications of new solitonic states within mid-IR supercontinuum generated in highly non-instantaneous fiber

Hepatic cirrhosis and recovery as reflected by Raman spectroscopy: information revealed by statistical analysis might lead to a prognostic biomarker

Hepatic cirrhosis is a severe chronic disease of the liver accompanied by massive changes in the physiology of the cells constituting the hepatic tissue. Success or failing of a therapeutic effort is difficult...

Single cell analysis in native tissue: Quantification of the retinoid content of hepatic stellate cells

Hepatic stellate cells (HSCs) are retinoid storing cells in the liver: The retinoid content of those cells changes depending on nutrition and stress level. There are also differences with regard to a HSC’s...

Multiplexed refractive index-based sensing using optical fiber microcavities

Optical fibers are promising tools for performing biological and biomedical sensing due to their small cross section and potential for multiplexing. In particular, fabricating ultra-small sensing devices...

Simultaneous measurement of temperature and refractive index using focused ion beam milled Fabry-Perot cavities in optical fiber micro-tips

Optical fiber micro-tips are promising devices for sensing applications in small volume and difficult to access locations, such as biological and biomedical settings. The tapered fiber tips are prepared...

Gold-reinforced silver nanoprisms on optical fiber tapers – a new base for high precision sensing

Due to their unique optical properties metallic nanoparticles offer a great potential for important applications such as disease diagnostics, demanding highly integrated device solutions with large refractive...

A fast microfluidic based 30-barrel application system to functionally characterize ligand-gated ion channels

The interaction of ligands with the binding site in ligand-gat-ed ion channels is usually characterized by measuring the steady-state concentration-activation relationships. In addi-tion to this, the kinetics...

Third harmonic generation in exposed-core microstructured optical fibers

Inter-modal phase-matched third harmonic generation has been demonstrated in an exposed-core microstructured optical fiber. Our fiber, with a partially open core having a diameter of just 1.85 µm, shows...

Ultrabroadband perfect imaging in terahertz wire media using single-cycle pulses

Slabs formed by wire medium metamaterials are capable of transmitting evanescent waves over several wavelengths,and enable perfect imaging of field patterns with deeply subwavelength features over such...