Spectroscopy and Imaging

The research department focuses on the research, development and implementation of innovative optical/photonic methods and tools for multiscale spectroscopy and multimodal imaging methods together with particle- and chip-based molecular point-of-care concepts for analytics, diagnostics and therapy in the fields of medicine, life and environmental sciences, quality and process analytics and pharmacy. The implementation of novel fibre concepts for spectroscopy and imaging as well as fibre-based sensor technology, strategies for spectroscopic high-throughput measurements and field-resolved optical precision measurement methods open up new analytical fields of application. The use of surface-enhancing Raman and IR detection methods to increase the sensitivity of spectroscopic methods round off the department's research profile. In general, the research department pursues the goal of covering the entire analytical measurement chain, whereby sample preparation and processing methods that can be used decentrally and independently of the laboratory are investigated and implemented in the overall workflow. Statistical, chemometric and image analysis methods as well as machine learning are researched and used to analyse the data obtained. Crucially, corresponding control and evaluation software is developed in-house, driving automation and enabling advanced diagnostic photonics. This allows us to optimize and automate data analysis using machine learning techniques.

Driven by the institute’s motto, ‘From Idea to Instruments,’ we are committed to translating our research findings into market-ready solutions. The Medicars device delivers rapid tissue diagnostics, providing surgeons with high-resolution, multimodal images within minutes to enhance disease understanding; its compact, adaptable system integrates seamlessly into any operating room for real-time, clinically relevant insights, such as precise tumor detection. The Raman2Go^TM platform embodies our extensive knowledge and expertise in the instrumentation of compact and user-friendly Raman microscopes for in vitro cell diagnostics, boasting a high degree of automation. Coupled with the RamanBioAssay^TM – a complete ‘sample to answer’ workflow – our integrated sample preparation and acquisition units are enabling drug interaction studies, such as those commonly used in antibiotic susceptibility testing. Furthermore, the RamanCellAssay^TM investigates cells associated with a range of disease profiles, providing valuable insights for disease understanding and potential therapeutic development.