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Femtosecond laser micromachining triple-modality optical fiber sensor with multiband optical decoupling for simultaneous dual-biomarkers and temperature monitoring
To address the insufficient information from single-parameter biological detection, this study proposes a multi-parameter optical biosensing scheme based on femtosecond laser micromachining (FLM), enabling...
PublicationsEngineering Aptameric Responsive Photonic Biosensor Based on Cholesteric Liquid Crystal Network for the Detection of Anatoxin
The rapid and reliable detection of cyanobacterial toxins remains a pressing challenge for environmental monitoring. In this work, we present a novel portable optical biosensor fabricated entirely from...
PublicationsRaman signatures of single point defects in hexagonal boron nitride quantum emitters
Point defects in solid-state quantum systems are vital for enabling single-photon emission at specific wavelengths, making their precise identification essential for advancing applications in quantum technologies....
PublicationsGeneration of an Induced Pluripotent Stem Cell-Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments
Influenza viruses (IVs) represent a significant global health issue, capable of causing seasonal epidemics and occasional pandemics with substantial morbidity and mortality. The emergence of viral resistance...
PublicationsA Splice-Free Dual-Mode Optical Fiber Biosensor for Sensitive and Temperature-Compensated β-Actin Detection via SPR and MZI Integration
This study presents a novel optical fiber biosensor configured for the concurrent measurement of β-actin (ACTB) and temperature. This device is built upon a single-mode optical fiber platform and uses...
PublicationsAutomatic optimization of flat-field corrections by evaluation and enhancement (EVEN) in multimodal optical microscopy
Uneven illumination affects all images acquired by optical microscopes, especially large, multicolour and nonlinear measurements. Although removal is possible with various algorithms, evaluating raw and...
PublicationsQuantitative optical nanoscopy of mitochondrial-derived vesicles in neurons classifies pre-peroxisomal and clearing organelles
Healthy mitochondria are crucial for maintaining neuronal homeostasis. Their activity depends on a dynamic lipid and protein exchange through fusion, fission, and vesicular trafficking. Studying vesicles...
PublicationsHigh-Resolution Molecular Typing of Vancomycin-Resistant Enterococcus faecium from Romania and Bavaria: Combining Enhanced DNA Microarray and Next Generation Sequencing
Antimicrobial resistance poses a significant challenge for infection control, requiring thedevelopment of accurate and high-throughput diagnostic techniques. We expandedand optimized an existing DNA microarray...
PublicationsUnveiling the molecular dynamics of a nitrile-containing 5-lipoxygenase-activating protein antagonist in primary macrophages through Raman spectroscopy
The nitrile (–CN) functional group is a versatile pharmacophore motif that also serves as an intrinsic, bioorthogonal Raman tag in the silent wavenumber region (1800–2700 cm−1). Here, we exploit...
PublicationsInfluence of light incidence angle and polarization on the refractive index sensitivity of tightly-packed ellipsoidal gold nanoparticle layers
The effect of excitation angle and polarization on the bulk refractive index sensitivity (RIS) of hexagonally-arranged gold nanoparticles is studied through numerical simulations and experiments. Analytical...
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