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Nonresonant background removal in broadband CARS microspectroscopy using deep learning algorithms
Broadband Coherent anti-Stokes Raman (BCARS) microscopy is an imaging technique that can acquire full Raman spectra (400–3200 cm−1) of biological samples within a few milliseconds. However, the CARS...
PublicationsRamanBioAssay platform for fast and comprehensive characterization of pathogenic bacteria
Bacterial infections contribute significantly to the global burden of disease. Identification of bacteria and subsequent antimicrobial susceptibility testing are important tools to mitigate the severe...
PublicationsMeta-fibers: merging nanophotonics and fiber optics via 3D nanoprinting for taylored beam manipulation
Here, we will demonstrate how the fusion of optical fibers with nanostructures creates a new category of fiber-integrated devices – meta-fibers – that unlocks novel applications. We achieve this by...
PublicationsTechnological approaches towards a monolithic visible Pr3+-doped fluoride glass fiber laser
Research results of different technological approaches and key components that are necessary to develop a monolithic visible fiber laser based on an active Pr3+-doped fluoride glass fiber (ZBLAN) in combination...
PublicationsPhysics-informed neural networks for etaloning correction in Raman spectra using inverse modeling
Raman spectroscopy, valued for its ability to provide detailed molecular fingerprints, plays a crucial role in industrial and academic research. However, optical artifacts, such as etaloning, often compromise...
PublicationsSpecialty capillaries and multi-core optical fibres for applications in imaging and multi-modal spectroscopy
We present examples of recent developments on specialty optical fibers at Leibniz-IPHT. A dual-core dual-clad fiber for multi-modal analyses was fabricated by a stack and draw technique, where MCVD Ge-doped...
PublicationsCorrelated micro-spectroscopic labelling and analysis of leukocytes
We demonstrate identification of unstained leukocytes (white blood cells) in a full blood smear by discrete wavenumber mid-infrared (IR) imaging and spectroscopy. Using the novel technique of optical photothermal...
PublicationsPhysics-guided foundation model for universal speckle removal in ultrathin multimode fiber imaging
Ultrathin multimode fibers (MMFs) promise endoscopes with hair-scale diameters for accessing sub-millimeter anatomy, but in MMF far-field imaging the required small collection aperture drives speckle-dominated...
PublicationsDeformation enduring conveyance of structured light through multimode waveguides and its exploitation for flexible hair-thin endoscopes
Confocal and multi-photon microscopy are widely used for in-vivo fluorescence imaging of biological tissues such as the brain, offering non-invasive access up to ~1 mm depth without major loss in performance....
PublicationsHair-thin confocal fluorescence endo-microscopy for deep-brain in-vivo imaging
Confocal and multi-photon microscopy are widely used for in-vivo fluorescence imaging of biological tissues such as the brain, offering non-invasive access up to ~1 mm depth without major loss in performance....
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