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Uptake of fatty acids by a single endothelial cell investigated by Raman spectroscopy supported by AFM

Raman spectroscopy is an attractive tool in identification cells, especially when studying cellular processes, including lipid droplets (LDs) formation. In this work, confocal Raman imaging was used to...

Miniaturized real-time PCR for rapid and selective identification of Legionella pneumophila in water samples

Legionella pneumophila are gram negative pathogenic water organisms with worldwide significance. Current methods for detection of these pathogens are time and/or cost intensive. We describe a miniaturized...

Photonic monitoring of treatment during infection and sepsis: development of new detection strategies and potential clinical applications

Despite the strong decline in the infection-associated mortality since the development of the first antibiotics, infectious diseases are still a major cause of death in the world. With the rising number...

Bridging Volume Levels in Droplet-based Microfluidics – Automated Electro-coalescence in Series of Droplet Sets

Digital microfluidics make use of a wide range of different droplet volumes. Droplet volumes in the range from pL to µL are applied in two different principles: emulsion based droplet processing and channel...

corr2D: Implementation of Two-Dimensional Correlation Analysis in R

In the package corr2D two-dimensional correlation analysis is implemented in R. This paper describes how two-dimensional correlation analysis is done in the package and how the mathematical equations are...

Yb3+-doped rod-type amplifiers with local adiabatic tapers for peak power scaling and beam quality improvement

The use of short local tapers in large mode area fiber amplifiers is proposed for peak power scaling while maintaining good beam quality. To avoid modal distortions, the powder-sintering (REPUSIL) method...

Common mistakes in cross-validating classification models

The common mistakes of cross-validation (CV) for the development of chemometric models for Raman based biological applications were investigated. We focused on two common mistakes: the first mistake occurs...

Multimodal image analysis in tissue diagnostics for skin melanoma

Early diagnosis is the corner stone for a successful treatment of most diseases including melanoma, which cannot be achieved by traditional histopathological inspection. In this respect, multimodal imaging,...

Raman microspectroscopy a promising tool for identifying the causative microorganism(s) in patient urine sample and detecting contaminants

Emerging young vibrational spectroscopists

This special issue of Vibrational Spectroscopy focuses on prominent young vibrational spectroscopist undertaking an impressive range of research whose work has the potential to influence future directions...