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Universal inverse modelling of point spread functions for SMLM localization and microscope characterization

The point spread function (PSF) of a microscope describes the image of a point emitter. Knowing the accurate PSF model is essential for various imaging tasks, including single molecule localization, aberration...

Selective plane activation structured illumination microscopy

Resolution enhancement in structured illumination microscopy is hindered when volumetric samples are observed owing to background signals from out-of-focus planes. In this study, we utilized selective...

Towards in vivo molecular imaging of the retina: OCT-guided Raman spectroscopy

Faraday effect sensing of single-molecules by graphene-based layered structures

To investigate the sensing properties of the Faraday effect in graphene in terahertz (THz), we consider the modulations of Dirac gaps in graphene when gas molecules are adsorbed to its surface. Here, the...

Label-free biomedical optical imaging

Label-free optical imaging employs natural and non-destructive approaches to visualize biomedical samples for both biological assays and clinical diagnosis. At present, this field revolves around multiple...

PEGylated Chitosan Nanoparticles Loaded with Betaine and Nedaplatin Hamper Breast Cancer: In Vitro and In Vivo Studies

The current study investigates the anticancer effects of PEGylated chitosan nanoparticles (CS NPs) coloaded with betaine (BT) and nedaplatin (ND) on breast adenocarcinoma (MCF-7) cells and breast cancer-bearing...

Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections

For the progress of point-of-care medicine, where individual health status can be easily and quickly monitored using a handheld sensor, saliva serves as one of the best-suited body fluids thanks to its...

Metafiber transforming arbitrarily structured light

Structured light has proven useful for numerous photonic applications. However, the current use of structured light in optical fiber science and technology is severely limited by modemixing or by the lack...

Turning on hotspots: supracolloidal SERS probes made brilliant by an external activation mechanism†

We achieved external activation of local hot-spot sites in supracolloidal assembly structures. The concept was demonstrated by boosting surface-enhanced Raman scattering (SERS) efficiency by one order...

Laboratory-Based Correlative Soft X-ray and Fluorescence Microscopy in an Integrated Setup

Correlative microscopy is a powerful technique that combines the advantages of multiple imaging modalities to achieve a comprehensive understanding of investigated samples. For example, fluorescence microscopy...