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Microfluidic Network Simulations Enable On-demand Prediction of Control Parameters for Operating Lab-on-a-chip-devices
Reliable operation of lab-on-a-chip systems depends on user-friendly, precise, and predictable fluid management tailored to particular sub-tasks of the microfluidic process protocol and their required...
PublicationsLooking for a perfect match: Multimodal combinations of Raman spectroscopy for biomedical applications
Raman spectroscopy has shown very promising results in medical diagnostics by providing label-free and highly specific molecular information of pathological tissue ex vivo and in vivo. Nevertheless, the...
PublicationsMultimodal scanning microscope combining optical coherence tomography, Raman spectroscopy and fluorescence lifetime microscopy for mesoscale label-free imaging of tissue
Multimodal optical imaging of tissue has significant potential to become an indispensable diagnostic tool in clinical pathology. Conventional bright-field microscopy provides contrast based on attenuation...
PublicationsCharacteristics of normal human retinal pigment epithelium cells with extremes of autofluorescence or intracellular granule count
Background: Cells of the retinal pigment epithelium (RPE) accumulate different kinds of granules (lipofuscin, melanolipofuscin, melanosomes) within their cell bodies, with lipofuscin and melanolipofuscin...
PublicationsIn situ photothermal deflection spectroscopy revealing intermolecular interactions upon self-assembly of dye monolayers†
We demonstrate the potential of photothermal deflection spectroscopy (PDS) to study the self-assembly of dye monolayers in situ. Beyond the determination of adsorption kinetics at specific wavelengths,...
PublicationsPEGylation of Guanidinium and Indole BearingPoly(methacrylamide)s – Biocompatible Terpolymers forpDNA Delivery
This study describes the first example for shielding of a high performing terpolymer that consists of N-(2-hydroxypropyl)methacrylamide (HPMA), N-(3-guanidinopropyl)methacrylamide (GPMA), and N-(2-indolethyl)methacrylamide...
PublicationsLaboratory-Developed Tests: Design of a Regulatory Strategy in Compliance with the International State-of-the.-Art and the Regulation (EU) 2017/746 (EU IVDR [In Vitro Diagnostic Medical Device Regulation])
Purpose This study aimed at the development of a regulatory strategy for compliance of laboratory-developed tests (LDTs) with requirements of the Regulation (EU) 2017/746 (“EU-IVDR”) under consideration...
Publications | 28.07.2021String-Attached Oligothiophene Substituents Determine the Fate of Excited States in Ruthenium Complexes for Photodynamic Therapy
We explore the photophysical properties of a family of Ru(II) complexes, Ru-ip-nT, designed as photosensitizers for photodynamic therapy (PDT). The complexes incorporate a 1H-imidazo[4,5-f][1,10]-phenanthroline...
PublicationsNoise Sources and Requirements for Confocal Raman Spectrometers in Biosensor Applications
Raman spectroscopy probes the biochemical composition of samples in a non-destructive, non-invasive and label-free fashion yielding specific information on a molecular level. Nevertheless, the Raman effect...
PublicationsSingle-Photon Detection with a Josephson Junction Coupled to a Resonator
We use a semiclassical formalism to optimize a microwave single-photon detector based on switching events of a current-biased Josephson junction coupled to a resonator. To detect very rare events, the...
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