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Raman Spectroscopy and Imaging in Bioanalytics

An automated microfluidic platform for the screening and characterization of novel hepatitis B virus capsid assembly modulators

To date, hepatitis B virus (HBV) capsid assembly modulators (CAMs), which target the viral core protein and induce the formation of non-functional viral capsids, have been identified and characterized...

Identifcation of infammatory markers in eosinophilic cells of the immune system: fuorescence, Raman and CARS imaging can recognize markers but diferently

Eosinophils (Eos) play an important role in the immune system’s response releasing several infammatory factors and contributing to allergic rhinitis, asthma, or atopic dermatitis. Since Eos have a relatively...

Nondestructive 3D imaging and quantification of hydrated biofilm matrix by confocal Raman microscopy coupled with non-negative matrix factorization

Biofilms are ubiquitous in natural and engineered environments and of great importance in drinking water distribution and biological wastewater treatment systems. Simultaneously acquiring the chemical...

A Model System for Sensitive Detection of Viable E. coli Bacteria Combining Direct Viability PCR and a Novel Microarray-Based Detection Approach

We established an innovative approach that included direct, viability, and nested PCR for rapid and reliable identification of the fecal indicator organism Escherichia coli (E. coli). Direct PCR enabled...

Activating [FeFe] hydrogenase mimic for hydrogen evolution under visible light**

Inspired by the active center of the natural [FeFe] hydrogenases, we designed a compact and precious metal-free photosensitizer-catalyst dyad (PS-CAT) for photocatalytic hydrogen evolution under visible...

Time-of-flight 3D imaging through multimode optical fibers

Time-of-flight three-dimensional (3D) imaging has applications that range from industrial inspection to motion tracking. Depth is recovered by measuring the round-trip flight time of laser pulses, typically...

Search for topological defect dark matter with a global network of optical magnetometers

Ultralight bosons such as axion-like particles are viable candidates for dark matter. They can form stable, macroscopic field configurations in the form of topological defects that could concentrate the...

Double Antiresonance Fiber Sensor for the Simultaneous Measurement of Curvature and Temperature

Antiresonant hollow core fibers (ARHCFs) have gained some attention due to their notoriously attractive characteristics on managing optical properties. In this work, an inline optical fiber sensor based...

Hepatectomy-Induced Alterations in Hepatic Perfusion and Function – Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function

Liver resection causes marked perfusion alterations in the liver remnant both on the organ scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level). These changes in perfusion...