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Application of molecular SERS nanosensors: where we stand and where we are headed towards?

Molecular specific and highly sensitive detection is the driving force of the surface-enhanced Raman spectroscopy (SERS) community. The technique opens the window to the undisturbed monitoring of cellular...

Removing interference-based effects from infrared spectra – interference fringes re-revisited

Substantial refractive index mismatches between substrate and layers lead to undulating baselines, which are known as interference fringes. These fringes can be attributed to multiple reflections inside...

Organic linkage controls the photophysical properties of covalent photosensitizer-polyoxometalate hydrogen evolution dyads

Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad

Dyads consisting of a photochromic switch covalently linked to a fluorescent dye allow the emission from the dye to be controlled by reversible photoisomerization of the switch; one form of the switch...

Comparison of multiscale imaging methods for brain research

A major challenge in neuroscience is how to study structural alterations in the brain. Even small changes in synaptic composition could have severe outcomes for body functions. Many neuropathological diseases...

Fluorescence Microscopy of the HIV-1 Envelope

Human immunodeficiency virus (HIV) infection constitutes a major health and social issue worldwide. HIV infects cells by fusing its envelope with the target cell plasma membrane. This process is mediated...

Theory of four-wave mixing for bound and leaky modes

We present a comprehensive theory of four-wave mixing in waveguide geometries, providing a rigorous description of the dynamics of both bound as well as leaky modes within a single theoretical framework....

Bi-metallic Pd/Au Nanoparticles prepared by UV-Excimer Laser exposure

Multi-metallic nanoparticles are useful for applications in biophotonics or catalysis. Metal compounds alter the properties of pure metallic nanoparticles and thus expand the particle performance compared...

Molecular investigations on a chimeric strain of Staphylococcus aureus sequence type 80

A PVL-positive, methicillin-susceptible Staphylococcus aureus was cultured from pus from cervical lymphadenitis of a patient of East-African origin. Microarray hybridisation assigned the isolate to clonal...

Microfluidic Chamber Design for Controlled Droplet Expansion and Coalescence

The defined formation and expansion of droplets are essential operations for droplet-based screening assays. The volumetric expansion of droplets causes a dilution of the ingredients. Dilution is required...