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Multimodal Nonlinear Microscopy for Therapy Monitoring of Cold Atmospheric Plasma Treatment
Here we report on a non-linear spectroscopic method for visualization of cold atmospheric plasma (CAP)-induced changes in tissue for reaching a new quality level of CAP application in medicine via online...
PublicationsHigh-content screening Raman spectroscopy (HCS-RS) of panitumumab-exposed colorectal cancer cells
Raman spectroscopy can provide the biomolecular fingerprint of a cell in a label-free manner. Although a variety of clinical and biomedical applications have been demonstrated, the method remains largely...
PublicationsFiber-array-based Raman hyperspectral imaging for simultaneous chemical selective monitoring of particle size and shape of active ingredients in analgesic tablets
The particle shape, size and distribution of active pharmaceutical ingredients (API) are relevant quality indicators of pharmaceutical tablets due to their high impact on the manufacturing process. Furthermore,...
PublicationsLabel-free CARS microscopy through a multimode fibre endoscope
Multimode fibres have recently been employed as high-resolution ultra-thin endoscopes, capable of imaging biological structures deep inside tissue in vivo. Here, we extend this technique to label-free...
PublicationsCytosolic innate immune pathway activation by Gram-positive bacteria during sepsis
Organ damage and mortality in sepsis have been attributed to deleterious and inappropriate host response during infection. Over the course of sepsis a systemic hyper inflammatory response as well as innate...
PublicationsUse of meat juice and blood serum with a miniaturised protein microarray assay to develop a multi-parameter IgG screening test with high sample throughput potential for slaughtering pigs
Background: Serological screening of pig herds at the abattoir is considered a potential tool to improve meat inspection procedures and herd health management. Therefore, we previously reported the feasibility...
PublicationsRapid antimicrobial susceptibility testing (AST) using Raman spectroscopy combined with a multiwell-dielectrophoresis chip
Introduction: Over the past yearsmulti-resistant pathogens have become an acute healthcare problem worldwide, which also critically affects sepsis patients. In order to initiate appropriate antibiotic...
PublicationsCholesterol supplementation protects hepatocytes against the cholesterol-dependent pore-forming toxin pneumolysin
Introduction: Pneumolysin (PLY) is a major virulence factor of Streptococcus pneumonia and crucial for the pathogenesis of invasive pneumococcal disease and sepsis following community-acquired pneumonia...
PublicationsPhotonic imaging can reveal localization of bacteria during hematogenous osteomyelitis
Introduction: One possible long-term consequence of sepsis is hematogenous osteomyelitis, i.e. the spread of bacteria from the blood stream to the bone. The clinical picture of this disease is swelling...
PublicationsMechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density
Regulation of plasma membrane curvature and composition governs essential cellular processes. The material property of bending rigidity describes the energetic cost of membrane deformations and depends...
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