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Non-linear multimodal imaging characteristics of early septic liver injury in a mouse model of peritonitis

Sepsis constitutes a life-threatening organ failure caused by a deregulated host response to infection. Identifying early biomolecular indicators of organ dysfunction may improve clinical decision-making...

Absolute Absorption Measurements in Optical Coatings by Laser Induced Deflection

Absolute measurement of residual absorption in optical coatings is steadily becoming more important in thin film characterization, in particular with respect to high power laser applications. A summary...

Richard g. Brereton: Chemometrics: data driven extraction for science, 2nd. ed.

Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology

We present an approach for fabrication of reproducible, chemically and mechanically robust functionalized layers based on MgF2 thin films on thin glass substrates. These show great advantages for use in...

High-throughput screening Raman microspectroscopy for assessment of drug-induced changes in diatom cells

High-throughput screening Raman spectroscopy (HTS-RS) with automated localization algorithms offers unsurpassed speed and sensitivity to investigate the effect of dithiothreitol on the diatom Phaedactylum...

Biomimetic light dilution using side-emitting optical fiber for enhancing the productivity of microalgae reactors

Photoautotrophic microbes present vast opportunities for sustainable lipid production, CO2 storage and green chemistry, for example, using microalgae beds to generate biofuels. A major challenge of microalgae...

Diffusion dynamics of the cytosolic peroxisomal import receptor PEX5

Peroxisomes are cell organelles with a size of 0.3-0.6 μm in mammalian cells, fulfilling many different functions like the oxidation of fatty acids, detoxification of reactive oxygen species as well as...

Anti-HIV antibody-lipid interactions enhance affinity for the native Env glycoprotein as revealed by single virion STED microscopy

The Env glycoprotein is the only viral protein exposed on the HIV-1 surface and thus, constitutes a prime target in the antiviral immune response. Most antibodies targeting Env offer protection against...

Wavefront shaping for low backgound, high resolution STED-FCS in three dimensions

Fluorescence correlation spectroscopy (FCS) is a powerful tool to study molecular diffusion. However, the spatial resolution of FCS experiments is restrained by the diffraction limit and many diffusion...

Translational Biophotonics: From research into clinical applications