In the project “Continuous monitoring and automatic control of pharmaceutical processes, based on in-process measurement data and correlation models, using measurement systems coupled with process control at e.g. fluid bed granulation” (Asteroid), the research and development of Raman spectroscopic methods based on imaging and fiber optic concepts for inline process control and monitoring in fluid bed granulators for the pharmaceutical industry is in focus, whereby chemical information about the process is obtained.

In this context, technical parameters/measuring conditions such as spectral resolution, laser excitation wavelength, integration time as well as the concentration dependence, distribution and detection limit of the constituents have to be investigated on model samples outside the fluid bed granulator. The investigated specific parameters are used as a guidepost for the required device specification, on the basis of which a technical concept is created, which is optimized for the problem.

Within the framework of the research project, two concepts will be pursued. In cooperation with the partners, the functional patterns will be integrated into a fluid bed granulator and evaluated.

The project is financed by the Free State of Thuringia under the number 2016 FE 9054 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).