Deutschland kommt bei der Bekämpfung von Infektionskrankheiten und antimikrobieller Resistenzen eine zentrale Rolle zu. Als Hochleistungsmedizinland kann Deutschland Innovationsmotor im Kampf gegen Infektionen sein. Mit der Deutschen Antibiotika-Resistenzstrategie DART2020 und massiver Unterstützung europäischer Initiativen wie der Global Antibiotic Research and Development Partnership hat Deutschland diesen Kampf in den vergangenen Jahren vorangetrieben. Trotz einzelner Erfolge dürfen die Anstrengungen nicht nachlassen.
Applying modern microscopic methods biomedical mechanisms down to the sub-micron range can be visualized. Both, the development of novel methods and devices for light microscopy as well as advancing known techniques are in the research focus of our work group. Tight cooperation with biological and medical research groups enables the individual and application-oriented optimization of the techniques aiming for a better understanding of biomedical processes. One goal is, for instance the dynamic real time visualization of receptor functions or poly-microbial infection.
The development of a microscope for fast live cell imaging providing an optical resolution of 50 nm and multiple colors is the long-term objective.
The interaction between laser irradiation and optical materials as well as dielectric coatings can be investigated nondestructively by exploiting laser spectroscopic methods. Both, improving existing as well as developing new laser sources e.g. for biomedical applications is an additional target of our research.
Fluorescence microscopy with highest resolution: This focuses on improving the resolution of fluorescence microscopes.
Alternative microscopic approaches: Here we develop various microscopic techniques in order to enhance detection speed and sensitivity, reduce bleaching or gather different microscopic information e.g. from multispectral Raman scattering.
Development of novel algorithms for image processing: Since many microscopic methods are dedicated to complex image processing, we develop diverse algorithms, particularly for image reconstruction or deconvolution.
High sensitive detection of small losses in optical materials and coatings: We focus on the absolute detection of smallest absorption and their origin, as well as the determination of smallest optical losses, e.g. for characterization of high reflective mirrors.