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Research Department Microscopy

Scientific Profile

Applying modern microscopy methods, biomedical mechanisms down to the sub-micron range can be visualized. Our work group focuses both on developing novel methods and devices for light microscopy as well as on improving established techniques. Tight cooperation with biological and medical research groups enables the individual and application-oriented optimization of the techniques aiming for a better understanding of biomedical processes. One goal is, for instance, the dynamic real time visualization of receptor functions or poly-microbial infection. 

By using modern 3D-printing techniques we are able to develop cost-efficient and yet powerful microscopes for education and research.

With the help of laser-based methods, we can investigate mechanisms of interaction between laser radiation and optical materials, as well as dielectric optical coatings destruction-free. We are developing highly sensitive testing methods such as laser-induced deflection and Cavity-Ring-Down.

Figure 1: Actin filaments (red) and nucleus (blue) of a Hela-cell, imaged with normal fluorescence microscopy (top) and SIM (bottom).
Figure 2: UC2 – 3D-printed modular optics system for research and education.
Figure3: Absorption and fluorescence of different defects/impurities in the same crystal type (Sapphire) under deep UV laser irradiation.

Research Topics

  • Fluorescence super-resolution microscopy 
  • Imaging for medical diagnosis
  • Alternative microscopic methods
  • Improvement of image reconstruction algorithms
  • Highly sensitive detection of minimal losses in optical materials and coatings 

Our main focus of research is the development of microscopy methods, in particular for biomedical imaging. We are using modern techniques such as microscopy with a spatial resolution beyond the Abbe-limit of diffraction. Furthermore, we are developing affordable microscopes for education and research and algorithms for image processing.

Addressed application fields

  • Applying optical microscopy to biomedical questions
  • Modern super-resolution fluorescence microscopy (SIM, dSTORM, etc.) in biology and medicine
  • Hyper-spectral Raman imaging for medical research
  • Affordable microscopes for research and education through 3D-printing and smartphones
  • Apply artificial neuronal networks for solving inverse problems in microscopy (image deconvolution and 3D image reconstruction)
  • Material characterization in industrial environments

Application fields cover a broad range of modern optical techniques. In cooperation with groups from biology and medicine we investigate concrete problems from current biomedical research. Furthermore we are developing systems for material characterization which are being applied in industry.

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