Laterally Resolved and Direct Spectroscopic Evidence of Nanometer-Sized Lipid and Protein Domains on a Single Cell

in: Small (2011)
Richter, Marc; Hedegaard, Martin A.B; Lampen, Peter; Deckert-Gaudig, Tanja; Deckert, Volker
Tip-enhanced Raman spectroscopy is used as a label-free, nondestructive method for the direct mapping of nanometer-sized lipid and protein domains on the surface of a single cell (see graphic). Spectral unmixing allows the analysis and visualization of the different cellular surface components down to a spatial resolution of 10–20 nm.

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