Magnetic nanoparticles coated with carboxymethylated polysaccharide shells-Interaction with human cells

in: Journal of Magnetism and Magnetic Materials (2009)
Wotschadlo, Jana; Liebert, Tim; Heinze, Thomas; Wagner, Kerstin; Schnabelrauch, Matthias; Dutz, Silvio; Müller, Robert; Steiniger, Frank; Schwalbe, Manuela; Kroll, Torsten C.; Höffken, Klaus; Buske, Norbert; Clement, Joachim H.
The interaction of magnetic core shell nanoparticles with living cells depends on the structure of the shell. In this paper we demonstrate a strong difference in the cell–nanoparticle interaction depending on the backbone of carboxymethylated polysaccharides used as shell material. Carboxymethyl cellulose with its β-1-4 linked structure and the carboxymethylated pullulan [α-1→6 linked maltotriose with α-1-4 linkages] show a constant interaction rate with both, tumor cells and leukocytes. In contrast, carboxymethyldextran with a α-1→6 linked backbone exhibits a rapid interaction kinetic with tumor cells that is reduced with leukocytes as target.

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