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Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology

We present an approach for fabrication of reproducible, chemically and mechanically robust functionalized layers based on MgF2 thin films on thin glass substrates. These show great advantages for use in...

High-throughput screening Raman microspectroscopy for assessment of drug-induced changes in diatom cells

High-throughput screening Raman spectroscopy (HTS-RS) with automated localization algorithms offers unsurpassed speed and sensitivity to investigate the effect of dithiothreitol on the diatom Phaedactylum...

Biomimetic light dilution using side-emitting optical fiber for enhancing the productivity of microalgae reactors

Photoautotrophic microbes present vast opportunities for sustainable lipid production, CO2 storage and green chemistry, for example, using microalgae beds to generate biofuels. A major challenge of microalgae...

Diffusion dynamics of the cytosolic peroxisomal import receptor PEX5

Peroxisomes are cell organelles with a size of 0.3-0.6 μm in mammalian cells, fulfilling many different functions like the oxidation of fatty acids, detoxification of reactive oxygen species as well as...

Anti-HIV antibody-lipid interactions enhance affinity for the native Env glycoprotein as revealed by single virion STED microscopy

The Env glycoprotein is the only viral protein exposed on the HIV-1 surface and thus, constitutes a prime target in the antiviral immune response. Most antibodies targeting Env offer protection against...

Wavefront shaping for low backgound, high resolution STED-FCS in three dimensions

Fluorescence correlation spectroscopy (FCS) is a powerful tool to study molecular diffusion. However, the spatial resolution of FCS experiments is restrained by the diffraction limit and many diffusion...

Translational Biophotonics: From research into clinical applications

Fluoride-Sulfophosphate/Silica Hybrid Fiber as a Platform for Optically Active Materials

Pressure-assisted melt filling (PAMF) of pre-fabricated micro-capillaries has been proven an effective way of fabricating hybrid optical fiber (HOF) from unusual combinations of materials. Here, we extend...

Molecular Specific and Sensitive Detection of Pyrazinamide and Its Metabolite Pyrazinoic Acid by Means of Surface Enhanced Raman Spectroscopy Employing In Situ Prepared Colloids

The prodrug pyrazinamide (PZA) is metabolized by the mycobacteria to pyrazinoic acid (POA), which is expelled into the extracellular environment. PZA resistance is highly associated to a lack of POA efflux....

Fabrication of 3D self-assembled UV-NIR broadband absorbers using metastable atomic layer deposition (MS-ALD)