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Polymorphism of amyloid fibrils formed by a peptide from the yeast prion protein Sup35: AFM and Tip-Enhanced Raman Scattering studies
Aggregation of prion proteins is the cause of various prion related diseases. The infectious form of prions, amyloid fibrils, exist as multiple strains. The strains are thought to represent structurally...
PublikationenSurface-enhanced Raman scattering characteristics of CuO: Mn/Ag heterojunction probed by methyl orange: effect of Mn2+ doping
Interest in the synthesis of hybrid substrates for surface-enhanced Raman scattering (SERS) has surged recently. Hereof, in the present work, a hybrid SERS substrate CuO : Mn/Ag heterojunction has...
PublikationenDetermination of Percent crystallinity of Side-Chain Crystallized Alkylated-Dextran Derivatives with Raman Spectroscopy and Multivariate Curve Resolution
We have developed a new self-consistent method for determining the absolute percent crystallinity of polymers directly with Raman spectroscopy. We estimate the ratio of the Raman cross-sections (ftrans/fgauche)...
PublikationenMultigrid MALDI mass spectrometry imaging (mMALDI MSI)
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is an important technique for the spatially resolved molecular analysis of tissue sections. The selection of matrices influences...
PublikationenMagnetic particle spectroscopy allows precise quantification of nanoparticles after passage through human brain microvascular endothelial cells
Crossing the blood–brain barrier is an urgent requirement for the treatment of brain disorders. Superparamagnetic iron oxide nanoparticles (SPIONs) are a promising tool as carriers for therapeutics because...
PublikationenPhotometric Detection of Nitric Oxide Using a Dissolved Iron(III) Corrole as a Sensitizer
Within this work the potential of an iron(III) corrole complex for its use in the detection of nitric oxide was explored. Therefore, the reversible conversion of an dissolved iron(III)corrole to its corresponding...
PublikationenTuning the polarity and surface activity of hydroxythiazoles – extending the applicability of highly fluorescent self-assembling chromophores to supra-molecular photonic structures
A small library of N,N-diethyl- and -diethanolsulfonamides of differently substituted 2-(2-pyridyl)- and 2-pyrazinyl-4-alkoxythiazoles has been synthesized and investigated in terms of their photophysical...
PublikationenPropagating and localized surface plasmon resonance sensing – A critical comparison based on measurements and theory
With its potential for ultrasensitive, label-free detection of molecular interactions, sensing methods based on the surface plasmon resonance (SPR) effect fully meet the requirements for modern analytical...
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