- Startseite
- Forschungsabteilungen
- Optisch-Molekulare Diagnostik und Systemtechnologie
- Publikationen
- An epidemic CC1-MRSA-IV clone yields false negative test results in molecular MRSA identification assays: a note of caution
An epidemic CC1-MRSA-IV clone yields false negative test results in molecular MRSA identification assays: a note of caution
in: Eurosurveillance (2020)
We investigated why a clinical meticillin-resistant Staphylococcus aureus (MRSA) isolate yielded false-negative results with some commercial PCR tests for MRSA detection. We found that an epidemic European CC1-MRSA-IV clone generally exhibits this behaviour. The failure of the assays was attributable to a large insertion in the orfX/SCCmec integration site. To ensure the reliability of molecular MRSA tests, it is vital to monitor emergence of new SCCmec types and junction sites.