Runtime: 01.11.2018 - 31.10.2023
LogicLab is a Marie Skłodowska-Curie Innovative Training Network (ITN) coordinated by Leibniz-IPHT and involves 9 beneficiaries and 6 partner organizations from Germany, Ireland, the Netherlands, Poland and Slovakia. The LogicLab network provides a multidisciplinary research environment for 14 early-stage researchers who are trained in the field of molecular logic sensors with the aim to overcome current obstacles in intracellular diagnostics. Since the introduction of molecular logic gates by the group of de Silva 20 years ago, multidisciplinary research approaches have focused on the realization of sensors, advanced drug delivery and pro-drug activation systems, computing, biomedical diagnostics and smart materials that exploit molecular logic gates. Important medical applications of molecular logic gates include e.g. photodynamic therapy (PDT) and point-of-care biomedical diagnostics. And, whereas these two examples show the potential of molecular logic sensing for medical diagnostics, the major obstacle, which is the transfer of this sensing concept from solution to a complex biological environment such as the living cell, has not been tackled to date, but holds promise for future diagnostics.
The objective of the LogicLab project is to explore a new concept of molecular logic sensing that can find application in intracellular sensing, critical care diagnostics and high-throughput screening.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 813920.