ThIMEDOP - Thuringian Innovation Center for Medical Technology Solutions (Diagnosis, Therapy - Optimization through Optical Technologies)
A main objective of the ThIMEDOP Innovation Centre is the creation of a central authority with incubator function for the Thuringian medical technology industry, in which the unmet medical need from medical clinical practice can be identified and solutions for this can be researched. The planned networking of doctors, engineers and basic researchers with each other and with partners from the medical technology industry in Thuringia will have a translation-promoting effect. In the future, the centre will be located in the CetraMed research building, which will be built on the premises of the University Hospital from 2019. Leibniz IPHT, the University Hospital of Jena and the Technical University of Ilmenau are jointly responsible for the Innovation Centre.
Duration: September 2018 - January 2023
The project is financed by the Free State of Thuringia under the number 2018 IZN 0003 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
Advanced-STED: Next-Generation Super-Resolution Optical STED Microscopy of Cellular Dynamics
In this project, two optical microscopes will be set up at Leibniz IPHT, which will enable an optimized observation of cellular dynamics. This will then serve for the more precise detection of various molecular processes in the context of disease-related changes in cells:
1) A light sheet microscope to record fast single cell dynamics with a coupling unit for a super-resolved STED microscope to observe molecular dynamics.
2) An endoscopically-based STED microscope for super-resolution imaging deep into tissues.
Duration: November 2018 - October 2021
The project is financed by the Free State of Thuringia under the number 2018 FGI 0022 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
BiopolarSpec: Development of innovative health technologies for the detection of pathological changes and for the visualization of local therapy efficiency by means of photonically polarizable biological species and photoinduced atomic force microscopy.
The integration of a innovative photoinduced atomic force microscopy (PiFM) into the well-developed research landscape at Leibniz IPHT should strengthen the leading position of the institute in the scientifically and economically important fields of optical health technologies and the life and environmental sciences and directly tie in with current medical and medical technology issues of infection research and therapy development, e.g. with the InfectoGnostics research campus and the Center for Sepsis Control and Care.
Duration: January 2019 - September 2020
The project is financed by the Free State of Thuringia under the number 2018 FGI 0023 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
Within the framework of the IR Photonics research project (photonic detection in the infrared spectral range in health technologies and environmental and energy research), vibrational spectroscopic imaging methods in the IR spectral range are to be researched and established at the Leibniz IPHT in order to address questions from the life and health sciences for which higher penetration depths in samples or tissues or higher sensitivities are required. These goals can be achieved by the lower absorption and scattering of tissue in the water window of 1-2 µm. New analytical methods will be established and new highly sensitive detectors and laser sources will be developed.
Duration: January 2018 - October 2019
The project is financed by the Free State of Thuringia under the number 2017 FGI 0018 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
The Opto Mikro project (innovative optical health technologies based on highly efficient and reproducible microfluidic chips) aims to integrate innovative biophotonic methods (Raman spectroscopy, fluorescence lifetime measurement and surface plasmon resonance spectroscopy) with precisely fitting microfluidic systems to meet the challenges of the transition to reproducible, standardised clinical use. The combination of microfluidic principles with optical measurement techniques thus opens up excellent opportunities for the sustainable transfer of these biophotonic technologies into everyday clinical practice.
Duration: November 2017 - October 2019
The project is financed by the Free State of Thuringia under the number 2017 FGI 0026 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
Construction of a multi-contrast intravital microscope for label-free imaging.
The aim of the project is to build an extremely versatile portable and modular multi-contrast microscopy platform for intravitreal imaging, which will support the imaging modalities of two photon excited fluorescence (TPEF), frequency doubling (SHG, second harmonic generation), coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS), two photon fluorescence lifetime imaging (FLIM), and Raman spectroscopy. The realization of such a multimodal microscopy platform for the investigation of cell culture samples up to organs and organisms, i.e. in vivo, will make it possible to conduct intravital microspectroscopic experiments, which have not been feasible up to now, which will open up fundamentally new possibilities for the understanding of life processes on the subcellular level up to the investigation of complex diseases as well as for the development of diagnostic procedures. Due to the portability of the set-up it is possible to use the device in the biophotonics laboratory of the Integrated Research and Treatment Centre for Sepsis and Sepsis Sequences (CSCC), the University Hospital or in the cell culture laboratory of the Abbe Center of Photonics, thus considerably expanding the spectrum of the Leibniz IPHT's work so far possible. This infrastructural networking between photonics and medicine will strengthen the application for large-scale interdisciplinary research projects. The planned infrastructure measure will make a significant contribution to further expanding and maintaining Leibniz IPHT's leading position in the scientifically and economically significant and sustainable field of biophotonics.
Project duration: 01.08.2015 to 31.07.2018
The project is financed by the Free State of Thuringia under the number 2015 FOR 0001 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
New spectroscopy-based methods for the characterization of infections and sepsis as well as the causative pathogen.
The funded infrastructure enables the Leibniz IPHT to investigate innovative biophotonic solutions for urgent medical questions, in particular for the diagnosis of infectious diseases and for the elucidation of pathogenesis mechanisms of infections that are difficult to treat, and to test them in initial research projects on biological and medical real samples. Within the framework of the project, the technological basis of the Leibniz IPHT is to be extended by special Raman and fluorescence technologies, but also by devices for the cultivation of biological samples, in order to develop new methods for the spectroscopic characterization of physiological interactions in infections. These new methods will shed light on the pathogenesis of difficult-to-treat chronic infections by characterizing the intracellular pathogen and rapidly recognizing the effect of antibiotics in order to identify resistant pathogens within a short period of time, but also to provide insights into the immune response to contact with microbial pathogens and to understand why patients develop sepsis.
Project duration: 03.02.2017 to 31.03.2019
The project is financed by the Free State of Thuringia under the number 2016 FGI 0010 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
In-SpekT - In-vivo spectroscopy for clinical transfer
A current research focus at Leibniz IPHT is the development of highly compact fiber-based probe concepts for the clinical in vivo application of Raman spectroscopy. The project aims to purchase spectrometers and lasers specifically for clinical studies in the field of biophotonic spectroscopy.
Duration: February 2017 - March 2019
The project is financed by the Free State of Thuringia under the number 2016 FGI 0011 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
Innovation Certificate A - Preparation, concretisation and detailed elaboration of the application "Leibniz Centre for Photonics in Infection Research (LPI)" as part of the national roadmap competition for research infrastructures of the BMBF.
The project comprises work on the preparation, concretisation and detailed elaboration of the application "Leibniz Centre for Photonics in Infection Research (LPI)" within the framework of the national roadmap competition for research infrastructures of the BMBF, which is currently being evaluated over several years by the project management agency DLR and the German Science Council.
The Leibniz Centre for Photonics in Infection Research is to establish itself as a user-open photonic centre that researches and develops fundamentally new solutions for the diagnosis, monitoring and experimental therapy of infections and puts them into routine use.
The project is financed by the Free State of Thuringia under the number 2016 IVN 0112 and co-financed by the European Union within the framework of the European Regional Development Fund (ERDF).
In the project "Continuous monitoring and automatic control of pharmaceutical processes, based on in-process measurement data and correlation models, using measurement systems coupled with process control at e.g. fluid bed granulation" (Asteroid), the research and development of Raman spectroscopic methods based on imaging and fiber optic concepts for inline process control and monitoring in fluid bed granulators for the pharmaceutical industry is in focus, whereby chemical information about the process is obtained.
In this context, technical parameters/measuring conditions such as spectral resolution, laser excitation wavelength, integration time as well as the concentration dependence, distribution and detection limit of the constituents have to be investigated on model samples outside the fluid bed granulator. The investigated specific parameters are used as a guidepost for the required device specification, on the basis of which a technical concept is created, which is optimized for the problem.
Within the framework of the research project, two concepts will be pursued. In cooperation with the partners, the functional patterns will be integrated into a fluid bed granulator and evaluated.
The project is financed by the Free State of Thuringia under the number 2016 FE 9054 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).
The fetal magnetocadiogram (fMKG) is an alternative to conventional prenatal monitoring methods. It has the advantage over fetal ECG that it is non-invasive and can be used in all phases of the second half of pregnancy. Currently common fMKG devices use SQUID as sensors and require magnetically shielded measuring chambers to achieve the necessary measuring resolution. Both of these factors hinder the further spread of the fMKG method. The project aims to overcome these obstacles. Optically pumped magnetometers (OPM) are qualified for the fMKG measurement. This qualification includes the operating mode of the OPM, its integration as arrays using MEMS methods and pumping via adapted microoptics. For the suppression of interference fields (from the heart of the mother and from the environment) it is planned to use the powers of the integrated OPM for the integration of adapted reference sensors, to use the signals of several OPM channels for the recording of the fMKG and a mother ECG. The parallel processing of all this information via software routines should open the way to unshielded measurement.
The quality of the fMKG measurements with this novel measuring system shall be demonstrated by the real recording of fMKG, also in comparison with an established SQUID measuring system.
The project is financed by the Free State of Thuringia under the number 2017 FE 9128 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).
The aim of the proposed joint project is to develop a new technology for the production of textile solar cells (DSCs), which serve the mobile power supply from renewable energies. The solar fabrics can be integrated into clothing ("Smart Textiles"), for example, and should be stable against the high mechanical stresses and environmental influences that occur, for example, when a garment is worn and washed. DSC-based solar fabrics are designed to meet the most important requirements for a portable energy source: they are lightweight, mechanically stable and yet flexible. In contrast to conventional silicon solar cells, their production is much simpler and more cost-effective since no vacuum coatings with toxic and explosive gases are required.
The project is financed by the Free State of Thuringia under the number 2016 FE 9028 and co-financed by the European Union within the framework of the European Regional Development Fund (ERDF).
The aim of the project is the development of a new and innovative additive technology for the production of complex optical components from quartz glass. The process is based on stereolithography (SLA), in which UV-curing resins are selectively exposed to laser radiation and three-dimensional shaped bodies are built up layer by layer. The hybrid SLA process consists of a two-stage SLA layer process in which modified glass pastes are applied in thin layers and then a second component is added with a print head. The glass pastes consist of a finely dispersed solid (SiO2) and a photosensitive binder and are specially developed for this process. The simultaneous processing of differently doped pastes should enable the construction of three-dimensionally structured components with variable geometry and composition. The produced components are thermally debinded and glazed under active gas atmosphere in a special newly developed gas pressure sintering furnace. After a surface finish, the resulting preforms are to be warped into structured optical fibers, which is an absolute novelty. In addition, optical components are also to be manufactured as examples.
Duration: January 2019 - December 2020
The project is supported by the Free State of Thuringia under the number 2018 FE 9100 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
Supported by the Free State of Thuringia with funds from the European Social Fund.
At Leibniz IPHT, the research group "Novel Preparation Technologies for Laser Active Special Preforms and Fibers" (RATI) will carry out fundamental investigations of low-damping, homogeneously doped and large-volume laser active materials based on quartz glass (Al-doped & Al-Tm-encoded) for use in microstructured special fibers. The basis of the planned research work for novel dopants to extend the functionality is the application of established technologies and the fiber technology center in Jena.
Duration: April 2019 - March 2022
Support code: 2018 FGR 0096
Supported by the Free State of Thuringia with funds from the European Social Fund.
The research group "Biophotonic analytics and diagnostics using hollow core fibres" (BIADIFA) aims to develop novel optical fibres for the use of innovative solutions in analytics, diagnostics, monitoring and therapy for medical applications and in the field of environmental monitoring.
Fiber sensor technologies play a key role here due to their extreme flexibility and miniaturization. The aim of this project is to make a significant contribution to the technological progress of photonic technologies as innovative tools in the fields of medicine, health and environmental analysis.
Support code: 2016 FGR 0051
Supported by the Free State of Thuringia with funds from the European Social Fund.
Supported by the Free State of Thuringia with funds from the European Social Fund.
The overall project "Fiber Technology for Researching the Power Limits of Laser Fibers" aims to investigate limiting effects of fiber power scaling for laser systems with excellent beam quality through fundamental investigations. The basis for this is the cooperation between the Leibniz IPHT Jena and the Fraunhofer IOF Jena, which has been proven over many years and whose competencies complement each other excellently in the subject matter applied for here. The synergy of the two subprojects will make it possible to effectively advance this research.
One focus of Leibniz IPHT's research activities will be technological investigations into the realization of thulium- and holmium-doped laser fibers using gas phase doping to open up the spectral range around 2 µm. Gas phase doping is the method of choice for power scaling (cw & pulse power) using large fiber cores (LMA concept) with extremely homogeneous dopant distribution. In addition, concentration ranges of codotands (Al) can be developed, which are decisive for a high energy efficiency of powerful Tm-based fiber lasers (cross-relaxation effects).
Furthermore, coding with Ce is also to be done via the gas phase in order to suppress photo-darkening (PD) effects in Yb and Tm- doped fibers, which are regarded as a major cause of mode instabilities (MI). From this connection (PD & MI) arises, among other things, the necessity and opportunity for close cooperation with the research group of the IOF in order to gain new scientific knowledge on performance scaling.
Another focus of the research group is the investigation of new photosensitive fibers for the fiber-integrated realization of resonator mirrors.
The shift of the wavelength of fiber lasers into the eye-safe range by 2 µm opens up new fields for applications in medical technology or material processing (e.g. polymer surfaces) in addition to the increase of the mode instability threshold to be investigated. However, this requires a wavelength scalability (tunability) for addressing specific wavelengths around 2 µm. The concept of step-chirped gratings as variably addressable resonators, which has already been successfully applied in Yb-doped fiber lasers, is to be researched here and transferred to larger wavelengths for power scaling.
The joint activities of the research groups also serve to support the work on setting up the fiber technology center on the Beutenberg campus.
Funding code: 2015 FGR 0108
With the project "Fiber-based biosensor technology (FBS) - an innovative approach for biophotonics", investments are to be made in order to significantly expand the existing infrastructure at the Leibniz IPHT in the research area of fiber optics and thus to sustainably open up highly topical and new research fields in the fields of medicine or biotechnology. In line with the strategic orientation of the Leibniz IPHT to research and technologically develop new approaches in medicine and the life and environmental sciences, the unique properties of optical fibres are to be used for new solutions in medicine and biophotonics in order to establish Thuringia as a leading location for medical and life science sensor concepts and products.
The project is financed by the Free State of Thuringia under the number 2015 FGI 0011 and co-financed by the European Union within the framework of the European Regional Development Fund (ERDF).
In the project, a chemically highly selective and sensitive, miniaturized Raman module for the decentralized inline analysis of biomolecules in a fluidic system is to be investigated in order to meet the demand for mobile, decentralized analysis and diagnostic procedures in medicine, pharmacy, the environment and the food industry.
The project is financed by the Free State of Thuringia under the number 2015 FE 9012 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).
The aim of the research project "Research and Production of Highly Sensitive Photonic Detectors for Optical Health Technologies" (InphoDeG) is to expand the infrastructure for the simulation, production technologies and metrological characterization of photonic detectors. In order to successfully implement the focus on optical health technologies at the IPHT, it is necessary to expand and maintain a broad range of interlocking complementary technologies, which enable the technical implementation of different sensor concepts, e.g. using functionalized surfaces and quantum-based detection mechanisms, up to their technical integration into innovative imaging and highly sensitive measurement systems for medical application scenarios.
Here, the scientists essentially link three different working directions synergetically with each other:
This interdisciplinary approach leads to innovative detection approaches in the field of optical health technologies, such as spatially and temporally high-resolution spectroscopic methods for the investigation of life processes.
The project is supported by the Free State of Thuringia under the number 2015 FGI 0008 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).
"Innovationsgutschein" for the preparation of an R&D cooperation project with the topic: "Active and passive textile cooling systems based on nanoscale semiconductor materials by using the thermoelectric effect".
The "Innovationsgutschein" serves to prepare an FTI (Fast Track to Innovation) cooperation project for submission to the EU as part of Horizon 2020.
The work includes the development of the concrete task and the strategy of the project for the development of textile-based thermoelectric cooling systems for integration in clothing and for industrial applications, measures for the acquisition of the necessary cooperation partners as well as the execution of patent studies, literature searches and market analyses.
Project duration: 24.6.2016 to 15.10.2016
The project is supported by the Free State of Thuringia under the number 2016 IVN 0063 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).
Collaborative project: "Development of a modular multiplex detection system for plasmid-based antibiotic resistance monitoring (PbR - plasmid-based resistance detection)".
Subproject: "Development of a multiplex detection system of resistance genes by separation of natural plasmids from complex samples and subsequent detection of plasmid antibiotic resistance genes on a plasmonic microarray chip (PlasmidChip)".
Microbial antibiotic resistance is an increasing worldwide problem for patient care. The resistance is spread via independently replicating mobile plasmids, which are even exchanged between the bacteria across species. The main focus of the available monitoring systems is on hospitals. Natural plasmids, which are mainly exchanged between the pathogens in the environment, are currently not depicted.
The joint project therefore aims to develop a plasmid-based antibiotic resistance monitoring system. The aim is to use an innovative plasmid isolation method that is integrated into a microfluidic chip. Resistance testing will then be carried out, also integrated on the microfluidic chip, using a highly innovative and label-free plasmonic method. The signals will be read using imaging spectrometry. The joint project will benefit from the close integration of the experts and the coordination by the industrial partner integrating the entire system.
The project is supported by the Free State of Thuringia under the number 2018 FE 9039 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).
Duration: March 2019 - February 2022
SIOS Meßtechnik GmbH, Ilmenau (Project Coordinator)
Mildendo Ltd., Jena
University Hospital Jena, Institute for Infection Medicine and Hospital Hygiene
Supported by the Free State of Thuringia with funds from the European Social Fund.
The aim of the "MultiHoloDiag" research group is to investigate multiparameter measurements of the interaction of biomolecules with optical-holographic methods for use in medical diagnostics. Detection units based on holographic methods are used, which are also technologically suitable for on-site diagnostic use. The group develops solutions for preanalytics and for the label-free, highly sensitive detection of single molecule layers. The systems are developed and tested using clinically relevant samples.
Funding code: 2018 FGR 0095
Duration: January 2019 - December 2021
LogicLab: „Molecular logic lab-on-a-vesicle for intracellular diagnostics“ Funding period: 11/2018 – 10/2022
In the project LogicLab, scientists from various disciplines are investigating how dye molecules can be combined to form new logic gates. Using such supramolecular logic gates, they aim to detect cellular dysfunctions and thus diagnose the onset of diseases such as arteriosclerosis earlier than before. Within the project, 14 international doctoral students are working at nine universities, research institutions and companies in Germany, Ireland, the Netherlands, Poland and Slovakia. The aim of the Innovative Training Network (ITN) is to train highly qualified young researchers through professional exchange, intensive scientific training and the acquisition of nontechnical skills. (www.logiclab-itn.eu)
Coordinator: Leibniz-IPHT Jena
RA Detect: One Platform- Multiple biomarker detection of Rheumatoid Arthritis
In this EU-Indian project we develop an on-site detection diagnostic system that identifies multiple markers of rheumatoid arthritis. Rheumatoid arthritis is a complex, chronic autoimmune disorder causing chronic disability worldwide and prevalent in the ageing population.
Detection of single photons in the microwave range has a number of applications ranging from galactic dark matter axions searches to quantum computing and metrology. The novel FET-Open consortium SUPERGALAX proposes a novel approach to acquisition of extremely low energy microwave signals (~1 GHz), based on the general concept of a passive quantum detection. For such highly sensitive detector (quantum antenna) they intend to use is a coherent quantum network composed of a large amount of strongly interacting superconducting qubits embedded in a low dissipative superconducting resonator. Assessment of the progress will be done by testing arrays with increasing number of superconducting qubits by using complementary experiments with different single photon sources. The feasibility of the superconducting network detector for galactic dark matter axions search will be finaly tested by axion conversion experiment in a magnetic field. The consortium members are CNR, Leibniz IPHT, Ruhr University Bochum, Loughborough University KIT Karlsruhe and INFN, Italy.
WaterChip - DNA Biochip for on-site water pathogen detection including viablility and antibiotic resistance testing
Globally, nearly 6,000 children die each day due to water-related illnesses. The WaterChip consortium combines academic and industry partners with expertise in molecular biology (ILS Ahmedabad, India), bioanalytical services (Food GmbH, Germany), pathogen detection technology development (IPHT, Germany) and on-site detection technology (ABC Genomics, India), in order to realize a great innovative solution: Rapid (in less than 1-hr) detection platforms covering waterborne pathogens, their indicators, and associated sources of antibiotic resistance bacteria on a single chip.
ACTPHAST is a unique one-stop-shop solution for supporting photonics innovation
Currently 2 ACTPHAST projects are running to support innovation with Photonics.
• ACTPHAST4.0 is specially designed to support European companies who want to boost the innovation of their projects with photonics. This project is supported by the EU. (Grant Agreement No. 779472).
Learn more about ACTPHAST4.0
• ACTPHAST4R aims to support researchers who have a conceptional breakthrough and would like to realize their prototype (or some components for their prototype) with mature photonics technologies. This project is supported by the EU. (Grant Agreement No. 825051)
Learn more about ACTPHAST4R
With the combination of both projects we aim to bridge the gap between TRL1-2 up to TRL 5-6.
(Advanced Magnetic full Tensor Gradiometer). The exploration of deep-seated deposits as well as the investigation and re-evaluation of former mine sites may be vital for secoring the European industry with important minerals. AMTEG unites partners with magnetic instrumentation background, geophysical service providers and a mining company. Exploration will benefit from the new airborn instrumentation by enabling a new level of magnetic field resolution translating into higher quality of inversion and interpretation results. Further project partners are SUPRACON AG, Nordika Geophysics (Sweden), Geognosia (Spanien) et.al.
Computational materials sciences for efficient water splitting with nanocrystals from abundant elements
Modern society in Europe needs a source of energy that is generated without harming the environment. The efficiency of renewable energy converting devices such as water splitting with electrochemical cells based on nano-scaled oxides relies on a sensible choice of material components. This Action intends to focus on bridging the knowledge gaps between different theoretical methods and computer codes in order to facilitate the discovery of novel materials for energy conversion.
The network aims at fueling urgently needed collaborations in the field of correlated multimodal imaging (CMI), promoting and disseminating its benefits through showcase pipelines, and paving the way for its technological advancement and implementation as a versatile tool in biological and preclinical research. CMI relies on the joint multidisciplinary expertise from biologists, physicists, chemists, clinicians and computer scientists, and depends on coordinated activities and knowledge transfer between academia and industry, and instrument developers and users. This Action will consolidate these efforts, establish commonly-accepted protocols and quality standards for existing CMI approaches, identify and showcase novel CMI pipelines, bridge the gap between preclinical and biological imaging, and foster correlation software through networking, workshops and open databases. The network will raise awareness for CMI, train researchers in multimodal approaches, and work towards a scientific mindset that is enthusiastic about interdisciplinary imaging approaches in life sciences.
Cancer Nanomedicine - from the bench to the bedside
Nano2Clinic is the first, pan-European interdisciplinary network of representatives from academic institutions and small and medium enterprises including clinical research organizations (CROs) devoted to the development of nanosystems carrying anticancer drugs from their initial design, pre-clinical testing of efficacy, pharmacokinetics and toxicity to the preparation of detailed protocols needed for the first phase of their clinical studies. By promoting scientific exchanges, technological implementation and innovative solutions, the Action will provide a timely instrument to rationalize and focus research efforts at the EU level in dealing with the grand challenge of nanomedicine translation in cancer, one of the major and societal-burdening human pathologies.
European network for the promotion of portable, affordable and simple analytical platform is a COST Association supported platform of scientists working in different fields, end-users and instrument manufacturers that aim to match need of low-cost analytical techniques with expertise. The portASAP Cost Action aims to work toward this goal by involving scientists working in separation sciences, engineers, chemometricians and other scientific fields, with end-users without expertise in analytical chemistry and instrument manufacturers. PortASAP will provide a platform where analytical needs in applied areas can be matched with expertise. It will also provide formation and promote awareness regarding the potential of low-cost analytical techniques.
Enhancing process efficiency through improved temperature measurement
For many manufacturers, product quality and uniformity are critically dependent upon temperature. Accurate temperature measurement in industry, however, is still a challenge: errors from tens to hundreds of degrees Celsius are possible for processes such as welding, whilst thermometer accuracy can drift over time. For some existing thermometer types and newer optical fibre-based designs, there are few or no current methods to trace their calibration back to primary standards held by National Measurement Institutes (NMIs). This project will improve the accuracy of a range of thermometer types used in manufacturing, as well as undertaking validation of in-situ references standards for combustion flame temperature measurement. For industrial processes where surface temperatures can reach the 1300 ºC region, methods will be developed with target levels of uncertainty less than 3 ºC, the measurements traceable to standards held by NMI laboratories. With better product uniformity resulting from improved temperature control, European manufacturers will be able to achieve greater efficiency through reduced wastage costs.
Marie Skłodowska-Curie Innovative Training Network: FIbre NErve Systems for Sensing (FINESSE)
The objective behind FINESSE (FIbre NErvous Sensing SystEms) is to mimic the nervous system of living bodies by turning man-made and natural structures into objects that are sensitive to external stimuli owing to advanced distributed fibre-optic sensor technology, with the objective to either give early warning in case of possible danger or occurrence of damage, or to optimise the operation of the structure to allow for a sustainable use of natural resources and assets. 26 European universities, research centers and industrial partners have teamed up to set up this Innovative Training Network, with the common objective of educating and training 15 Early Stage Researchers (ESRs) in the development of a set of disruptive new optical ‘artificial nervous systems’ and to boost the industrial uptake of these sensors by technology transfer from academic research to the European optical fibre sensor industry.
Coordinator: École polytechnique fédérale de Lausanne – EPFL
LaserLab Europe - The Integrated Initiative of European Laser Research Infrastructures
Under Horizon2020, Laserlab-Europe has entered a new phase of its successful cooperation: the Consortium now brings together 33 leading organisations in laser-based inter-disciplinary research from 16 countries. Together with associate partners, Laserlab covers the majority of European member states. 22 facilities offer access to their labs for research teams from Europe and beyond.
For his research project LIFEGATE, Leibniz IPHT Head of Department Fiber Research and Technology Tomáš Čižmár received the well-recognized Consolidator Grant funded by the European Research Council (ERC) – a distinction for excellent scientists. Čižmár intends to study precisely processes of light propagation in multi-mode fibers. To eventually use the technology also in the micro endoscopy, the fibers must be above all flexible. That is indeed a challenge, because as the fibers bend, the transmitted image becomes distorted differently. The researcher is hoping to find a solution to this problem by understanding the propagation of light in the fiber more accurately. As well, Čižmár plans to increase the relatively slow speed of the transmission by employing faster graphics processors and better data processing algorithms.
MIB - Multi-modal, endoscopic biophotonic Imaging of bladder cancer for point-of-care diagnosis
Early Detection of Bladder Cancer: From 2016 - 2020, IPHT researches a novel endoscope for the quick diagnosis of bladder cancer as part of the 6-million-EU project MIB. Medical doctors will be able to detect whether and how deep cancer tissue has penetrated the inner wall of the bladder during a routine check-up without having to take a sample. The goal is to improve the treatment of patients and relieve the strain on the health care system.
Coordinator: Technical University of Denmark
The MSCA ITN MONPLAS offers an integrated transdisciplinary training program for young researchers in advanced detection technologies for measuring microplastics in fluids. Microplastics have been reported in marine environments worldwide. Accurate assessment of quantity and type is therefore needed. The MONPLAS network offers a unique opportunity for collaboration in the field among academic and industrial researchers and cooperation with international experts in research, development and characterisation of advanced technologies. MONPLAS possesses very high potential to have major impact on the European economy. This is reflected in the participation of the top-class consortium, including, for example, Aston University, Bruker, KTH, Shimdazu, Renishaw, the Free University of Brussels and the Leibniz-IPHT.
MOON - Multi-modal Optical Diagnostics for Ocular and Neurodegenerative Disease
MOON aims at improving the diagnosis of major ophthalmic and neurodegenerative diseases through the development of disruptive optical technology. The novel diagnostic platform combines the strength of complementary modalities, being Optical Coherence Tomography, Fluorescence Imaging, and Raman Spectroscopy. MOON includes a validation of the multimodal diagnostic system in a clinical setting focusing on age-related macula degeneration and Alzheimer’s disease as surrogates for other major diseases affecting the human eye and the brain. The eye serves as window to the brain, as the retinal neural tissue is equally affected by major neurodegenerative diseases as the brain tissue itself. Early signs of disease may therefore be diagnosed at an early state in a fully objective manner. This would have a huge societal impact on the quality of life of patients and their caretakers as well as on the national healthcare systems themselves.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 732969 (MOON). It is an initiative of the Photonics Public Private Partnership.
Leibniz-IPHT is coordinating a Europe-wide research project to investigate a multimodal imaging fiber probe that can diagnose critical sites in the human heart that are critical for the development of cardiac arrhythmias. Cardiac arrhythmias are considered one of the major causes of sudden cardiac death. In the project "Multimodal Fiber Optic Probe for Highly Resolved in Vivo Localization of Cardiac Fibrosis" (MultiFib), the Jena research team cooperates with partners from the Medical University of Vienna and the Institute of Rhythmology and Cardiac Modeling (Liryc) in Bordeaux, which specializes in the research and treatment of cardiac arrhythmias.
The European Commission is funding MultiFib as part of the ERA-NET programme in Horizon 2020 until April 2021.
MULTIPLY is a 5 year Marie Skłodowska-Curie COFUND Action co-ordinated by the Aston Institute of Photonic Technologies, Aston University, that offers interdisciplinary training for over 50 outstanding international experienced researchers in the areas of photonics science, technology and applications over the programme duration. The overall aim of the COFUND MULTIPLY project is to assist in the career development of the next generation of photonics research and innovation leaders. The MULTIPLY Partner Organization consortium comprises of 46 internationally leading academic and industrial partners covering the globe from China to Australia, & from Russia to Mexico. The partners will act as hosts for eligible fellows, providing excellence in postdoctoral training, mentoring career development opportunities, offering access to cutting edge facilities, fast-paced innovation activities and further industrial links.
„Nanocrystals in Fiber Lasers“
Enabling novel unique technologies: Leibniz-IPHT coordinates this Europe-wide research project to develop fibre lasers with new wavelengths. The powerful, robust fibre lasers are expected to significantly expand the spectral range achieved so far, thus enabling new applications in medicine and telecommunications. The European Union is supporting the project, in which research institutes from Spain, Poland and the UK and LASOS GmbH, Jena, Germany, are collaborating, within the framework of the "FET Open" programme for radically new future technologies. The project receives funding by the European Union of 3 million euros over four years. By incorporating nanocrystallites into a fibre, the scientists hope to open up areas that are relevant for biomedical applications but for which there are as yet no practical solutions. For example, a planned fibre laser aims at a spectral range in which tissue is very transparent, so that even deep layers become visible.
OpenInnoTrain is a new €2.5M research project focused on open innovation and research translation between academia and industry with a 22-member research consortium with partners from several countries. The project aims at enabling the untapped potential of European university researchers in getting their research outcomes to the market within the University‐Industry Cooperation (UIC) framework. This Open Innovation approach for research translation is the prerequisite for societal impact through value creation by embedding research‐generated knowledge into practices, transforming knowledge made available in academic publications to new or improved products and services and behavioural changes. Researchers in Europe and Australia will have the opportunity to spend from one month up to a year in Australia and in several European countries including Austria, Croatia, Denmark, Finland, Germany, Italy, the Netherlands, Norway, Portugal, Slovenia, UK and Spain. This is the first project that connects European and Australian research at this scale within such a global network of industrial partners and academic institutions. In addition to exchanges, the project will also include workshops, summer schools, masterclasses, seminars and hackathons in different locations across Europe with project partners.
OPTIcal fibre device for simultaneous Manometry, pH-metry and bilimetry in Oesophagus
The oesophagus is a hollow tube, which transports food from the mouth to the stomach. Dysfunction of the peristaltic transport mechanism causes a variety of diseases like gastro-oesophageal-reflux-disease (GERD), oesophageal adenocarcinoma, heartburn or pyrosis, achalasia and nutcracker oesophagus. When the clinical picture remains unclear the functionality of the oesophagus has to be examined with sensors. A clearly defined goal is to make these examinations faster and more comfortable to the patient. Main target of this project is an OPTIMO sensor, a portable device based on a fully optical technology capable to perform manometry, pH-metry and bilimetry within the same optical fibre catheter or by means of combined catheters so as to provide physicians a compact and reliable tool to perform exhaustive diagnosis in gastroesophageal reflux pathologies. The OPTIMO sensor based on a fully optical technology and offering the possibility of performing the measurement of the three parameters simultaneously by means of the use of a single or combined catheter would be definitely an innovative product in the gastro-oesophageal diagnostic scenario with high potential for worldwide market penetration and application developments.
Funded by Photonics Based Sensing ERA-NET Cofund
The aim of the MSCA Innovative Training Network PHAST (Photonics for Healthcare: multiscAle cancer diagnosiS and Therapy) is to develop an innovative training programme in the field of biophotonics able to offer society a team of highly skilled multidisciplinary scientists through a personalized PhD career development plan covering the fields of cutting edge diagnostics and therapy of cancer diseases. An early diagnosis and targeted treatment of cancer, which are of great importance to the European community, require the development of innovative diagnosis tools and non-invasive methods to monitor a therapy response. The main scientific goal of the PHAST-ETN action is to develop multiscale advanced photonic technologies for the diagnosis of cancer in vitro and in vivo and the monitoring of therapy for personalized medicine. Further network partners besides Leibniz-IPHT are the University of Parma, ICFO, the Medical University of Vienna, TYNDALL, HORIBA Jobin Yvon, Philips and Carl Zeiss Meditec AG.
Quantum based airborne EM/MAG system for fast 3D Earth mapping
The successful funding programme Eurostars supports international innovative projects led by research and development- performing small- and medium-sized enterprises (R&D-performing SMEs). With its bottom-up approach, Eurostars supports the development of rapidly marketable innovative products, processes and services that help improve the daily lives of people around the world. The Eurostars project QMag will develop a new airborne geophysical instrument which comprises a vector magnetometer having three orthogonal superconducting quantum interference device (SQUID) sensors. The system will have high sensitivity with noise < 10 fT/sqrt(Hz), and will have a wide dynamic range. This innovation will allow for the simultaneous measurement of the earth’s field and the audio frequency magnetotelluric (AFMAG) signals. This technology will be used for mapping geologic formations to great depth.
TRACE - Tracking and Assessing the Risk from Antibiotic Resistant Genes using Chip Technology in Surface Water Ecosystems
Given the serious public health threat posed by antimicrobial resistance, it is important to investigate the potential role of surface water in amplifying the emergence and spread of antimicrobial resistance and to assess the potential associated risk to human health. Research into the occurrence, fate, effect, and risk associated with the presence of antimicrobial resistant bacteria in such environments and the impact on human health is urgently needed for informed policy decisions.
TRACE will develop detection technologies that allow for a simpler on-site detection of antibiotic resistance, thereby enabling a much higher throughput and faster result-to-user turnaround. TRACE is a water research project funded by the first joint call of the Water Joint Programming Initiative (JPI).
E-SQUID (Development of SQUID-based multiplexers for lage Infrared-to-X-ray imaging detector arrays in astronomical research from space)
Recently, research in astrophysics has yielded amazing new insight in the origin, evolution and structure of the Universe, and fundamental processes governing this highly dynamical system.
Koordinator: HELSINGIN YLIOPISTO, Finland
BiophotonicsPlus: "Photonic appliances for life sciences and health”
BiophotonicsPlus is a transnational call for research and development project proposals on ‘photonic appliances for life sciences and health’, primarily aiming at the stimulation and support of innovative R&D projects which will translate existing biophotonic technologies and methods into appliances and put them into clinical, medical or industrial practice.
Projects funded via BiophotonicsPlus with Leibniz IPHT being either coordinator or partner:
High-resolution Microscopy for Living Cell Diagnostics: In the project Fast Life Cell Structured Illumination Microscopy (FastFibreSIM), a transnational consortium (Germany, UK) aims to improve the imaging speed of the SIM microscopy significantly to allow live cell imaging. This new microscope will enable life cell imaging of fast processes under physiological conditions. The project is running under the FP7 ERANET BiophotonicsPlus on "Photonic appliances for life sciences and health".
Optical needle sensors for therapy monitoring of inflammatory skin diseases to prevent recidives (PhotoSkin)
The PhotoSkin sensor will provide an entirely new access to clinically relevant information based on the three-dimensional lipid structure within psoriatic skin. Coordinated by Leibniz IPHT, the project combines a range of transnational complementary competences and experiences in innovative high-tech companies (Z-light Ltd/Latvia, Elfi-Tech Ltd/Israel and TOPTICA Photonics AG/Germany), and a research-intensive hospital (Charité, Germany).
Real-time multispectral flourescence spectroscopy using energy resolved single-photon detector arrays (Real-MFM)
The radical approach proposed here is to use a photon detector which discriminates single photons in terms of both time and energy. This technique demands performance in detection which closely approaches fundamental physical limits.
Raman4Clinics pools European expertise to step forward in the field of novel, label-free and rapid technologies based on a wide variety of Raman spectroscopies for the clinical diagnostics of body fluids, bacteria, cells and tissues. International interdisciplinary networking opportunities are offered between scientists within biophotonics, chemometricians and physicians/clinicians. Currently, the network has more than 150 members out of 26 countries.
Coordinator: Leibniz IPHT, Germany
FIBLYS - Building an Analyzing Focused Ion Beam for Nanotechnology
The project FIBLYS aims at developing an innovative nanostructuring, nanomanipulation and nanoanalysis instrument: a hybrid scanning probe (SPM) and dual beam focussed ion beam (FIB) instrument (including scanning electron microscopy (SEM) capabilities).
Coordinator: Leibniz IPHT Germany
HIGH EF - Large grained, low stress multi-crystalline silicon thin film solar cells on glass
HIGH-EF will provide the silicon thin film photovoltaic (PV) industry with a unique process allowing for high solar cell efficiencies (potential for >10%) by large, low defective grains and low stress levels in the material at competitive production costs.
Coordinator: Leibniz IPHT Germany
Chemotherapy is the standard care for the treatment of non-small cell lung carcinoma (NSCLC) patients, however most of non-small cell lung cancer tumours are not sensitive to this treatment. As an alternative to chemoterapy, target therapy with gefitinib (epidermal growth factor receptor-tyrosine kinase inhibitor) has been used in clinical practice in patients with tumours harbouring mutations in EGFR gene, improving their treatment effectiveness. The LungCARD project has developed a lab-on-a-chip device for the detection of EGFR mutations on circulating tumor cells from Non-Small Cell lung cancer (NSCLC) patients via gold-nanoparticle (AuNPs) based detection.
Nano3T - Biofunctionalized metal and magnetic nanoparticles for targeted tumour therapy
The cause of diseases is often unknown, but their origin can frequently be found at the biomolecular and cellular level situated on nm-scale. Early diagnostics combined with early intervention on that nanoscale is one of the holy grail of modern medicine.
Coordinator: Interuniversity Micro-electronics Centrum (IMEC), Leuven, Belgium
NanoPV - Nanomaterials and nanotechnology for advanced photovoltaics
The NanoPV project aims at making a breakthrough step-change in photovoltaics by the removal of a set of bottlenecks which have been identified to block the application of nanostructures for high-efficiency, low-cost solar cells.
Coordinator: STIFTELSEN SINTEF, Trontheim, Norway
COST Action PerspectH2O
PERSPECT-H2O is a 4-years COST Action integrating leading European groups and national research centers of more than 22 countries, focusing on a central theme of contemporary research in homogeneous photocatalysis and integration of supramolecular photocatalysts towards the construction of functional materials.
Coordinator: Leibniz IPHT, Germany
Dr. Stephen Warren-Smith from the Centre for Nanoscale BioPhotonics (CNBP), Adelaide/Australia is researching for two years at the Leibniz Institute of Photonic Technology (Leibniz IPHT). The Marie Skłodowska-Curie action program is supporting his research stay. The research of Dr. Warren-Smith focuses on the development of tiny fiber sensors for biomedical applications. These sensors will be adjusted to the requirements of the measurement of specific biological processes by improving the fiber design as well as the manufacturing operations. That way, innovative optical tools will be provided for life science as well as medical diagnostics.
Coordinator: Leibniz IPHT, Germany
RODSOL - All-inorganic nano-rod based thin-film solarcells
Thin film solar cells, based on non-toxic, abundant and air-stable silicon (Si) will probably, based on forecasts, dominate the photovoltaic market in the future and thus replace bulk Si from its leading position.
Coordinator: Leibniz IPHT, Germany
S-Pulse - Shrink-Path of Ultra-Low Power Superconducting Electronics
The proposed Support Action S-PULSE aims to prepare Superconducting Electronics (SE) for the technology generation beyond the CMOS scaling limits ("beyond CMOS").
Coordinator: Leibniz IPHT, Germany
SINAPS - Semiconducting Nanowire Platform for Autonomous Sensors
The aim of the SiNAPS project is to develop standalone “dust”-sized chemical sensing platforms that harvest energy from ambient electromagnetic radiation (light) and will enable miniaturisation below the current mm3 barrier.
Coordinator: UNIVERSITY COLLEGE CORK, Irland
SMARTER-SI: Smarter Access to Manufacturing for Systems Integration
SMARTER-SI is an Innovation Action that receives funding from the European Commission's Horizon 2020 Programme under Grant Agreement No. 644596, and the Swiss State Secretariat for Education, Research and Innovation (SERI). In order to provide access to manufacturing capabilities for SMEs, several European Research and Technology organisations (RTOs) joined efforts, among them Leibniz IPHT.
The core of the initiative is the networks of competence centres, usually research technology organisations (RTOs) or technology transfer-oriented university institutes who cluster a wide spectrum of technical and application knowledge to support innovation. Inspired by the Strategic Research Agenda of EPoSS, SMARTER-SI aims to develop an RTO Community Foundry Model (CFM) that will accelerate a wider deployment of SSI with greater access to design, manufacturing capabilities for prototyping, early validation and first production for SMEs to exploit in niche markets.
SOLID - Solid State Systems for Quantum Information Processing
The SOLID concept is to develop small solid-state hybrid systems capable of performing elementary processing and communication of quantum information. This involves design, fabrication and investigation of combinations of qubits, oscillators, cavities, and transmission lines, creating hybrid devices interfacing different types of qubits for quantum data storage, qubit interconversion, and communication.
Coordinator: CHALMERS TEKNISKA HOEGSKOLA AB, Sweden
WISC - Window Integrated Solar Collector
New INDIGO Partnership Programme on Energy Research- New INDIGO Initiative for the Development and Integration of India and European research. Today’s trend of increasing window areas especially in public and office buildings results in the problem of excess heat collection inside (greenhouse effect), which leads to higher energy consumption in air conditioning and thus for higher costs. In the EU-Indian project WISC we propose a novel principle of separating the heat (IR part) from the visible light and use it for energy generation, without scarifying parts of the window areas or otherwise reduce the visible illumination. This groundbreaking idea will be realized by a functionalized window including plasmonic nanoparticles, a waveguide arrangement, and thermoelectric conversion.
CanDo: Chip-sized Analysis Laboratory Used in the Early Detection of Cancer
The Leibniz Institute of Photonic Technology (IPHT) researches a miniature laboratory used in the early detection of pancreatic cancer together with nine European partners as part of the EU project CanDo, among them three companies (Bayer, Imec and Gilupi) as well as seven research organisations and universities.
Coordinator: University of Valencia, Spain
As part of the European Commission’s Marie Skłodowska Curie research fellowship program, Dr. Michael Vetter is researching a new method of manufacturing crystalline silicon thin-film solar cells on glass at IPHT for the next two years.
Coordinator: IPHT Jena, Germany
The EU-project HemoSpec develops an innovative photonic device for early, fast and reliable medical diagnosis of sepsis using only a minimal amount of a patient’s blood. The project involves two hospitals, the University Hospital in Athens and Germany’s Centre for Sepsis Control and Care (CSCC), as well as four companies: France’s Horiba Scientific; biomedical software company, Bmd (Portugal); ViroGates, an international Biotech company (Denmark); and biomedical instrument manufacturer, Data Med (Italy). HemoSpec combines three complementary biophotonic technologies into one device: automated microfluidic sample handling with integrated holographic blood count; simultaneous multiplex fluorescence biomarker sensing; and detailed Raman spectroscopic leukocyte characterisation.
Coordinator: Leibniz IPHT Jena, Germany