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Research Projects

EU-funded and co-financed projects

 Research project ThIMEDOP

ThIMEDOP - Thuringian Innovation Center for Medical Technology Solutions (Diagnosis, Therapy - Optimization through Optical Technologies) 

A main objective of the ThIMEDOP Innovation Centre is the creation of a central authority with incubator function for the Thuringian medical technology industry, in which the unmet medical need from medical clinical practice can be identified and solutions for this can be researched. The planned networking of doctors, engineers and basic researchers with each other and with partners from the medical technology industry in Thuringia will have a translation-promoting effect. In the future, the centre will be located in the CetraMed research building, which will be built on the premises of the University Hospital from 2019. Leibniz IPHT, the University Hospital of Jena and the Technical University of Ilmenau are jointly responsible for the Innovation Centre.

Duration: September 2018 - January 2023

The project is financed by the Free State of Thuringia under the number 2018 IZN 0003 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 Research project Advanced-STED

Advanced-STED: Next-Generation Super-Resolution Optical STED Microscopy of Cellular Dynamics

In this project, two optical microscopes will be set up at Leibniz IPHT, which will enable an optimized observation of cellular dynamics. This will then serve for the more precise detection of various molecular processes in the context of disease-related changes in cells: 

1) A light sheet microscope to record fast single cell dynamics with a coupling unit for a super-resolved STED microscope to observe molecular dynamics. 

2) An endoscopically-based STED microscope for super-resolution imaging deep into tissues. 

Duration: November 2018 - October 2021

The project is financed by the Free State of Thuringia under the number 2018 FGI 0022 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 

 

 

 Research Project BiopolarSpec

BiopolarSpec: Development of innovative health technologies for the detection of pathological changes and for the visualization of local therapy efficiency by means of photonically polarizable biological species and photoinduced atomic force microscopy.

The integration of a innovative photoinduced atomic force microscopy (PiFM) into the well-developed research landscape at Leibniz IPHT should strengthen the leading position of the institute in the scientifically and economically important fields of optical health technologies and the life and environmental sciences and directly tie in with current medical and medical technology issues of infection research and therapy development, e.g. with the InfectoGnostics research campus and the Center for Sepsis Control and Care.  

Duration: January 2019 - September 2020

The project is financed by the Free State of Thuringia under the number 2018 FGI 0023 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 Research project IR-Photonic

Within the framework of the IR Photonics research project (photonic detection in the infrared spectral range in health technologies and environmental and energy research), vibrational spectroscopic imaging methods in the IR spectral range are to be researched and established at the Leibniz IPHT in order to address questions from the life and health sciences for which higher penetration depths in samples or tissues or higher sensitivities are required. These goals can be achieved by the lower absorption and scattering of tissue in the water window of 1-2 µm. New analytical methods will be established and new highly sensitive detectors and laser sources will be developed. 

Duration: January 2018 - October 2019

The project is financed by the Free State of Thuringia under the number 2017 FGI 0018 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).

 

 

 Research project OptoMikro

The Opto Mikro project (innovative optical health technologies based on highly efficient and reproducible microfluidic chips) aims to integrate innovative biophotonic methods (Raman spectroscopy, fluorescence lifetime measurement and surface plasmon resonance spectroscopy) with precisely fitting microfluidic systems to meet the challenges of the transition to reproducible, standardised clinical use. The combination of microfluidic principles with optical measurement techniques thus opens up excellent opportunities for the sustainable transfer of these biophotonic technologies into everyday clinical practice. 

Duration: November 2017 - October 2019

The project is financed by the Free State of Thuringia under the number 2017 FGI 0026 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 Research Project Multicontrast Intravital Microscope

Construction of a multi-contrast intravital microscope for label-free imaging.

The aim of the project is to build an extremely versatile portable and modular multi-contrast microscopy platform for intravitreal imaging, which will support the imaging modalities of two photon excited fluorescence (TPEF), frequency doubling (SHG, second harmonic generation), coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS), two photon fluorescence lifetime imaging (FLIM), and Raman spectroscopy. The realization of such a multimodal microscopy platform for the investigation of cell culture samples up to organs and organisms, i.e. in vivo, will make it possible to conduct intravital microspectroscopic experiments, which have not been feasible up to now, which will open up fundamentally new possibilities for the understanding of life processes on the subcellular level up to the investigation of complex diseases as well as for the development of diagnostic procedures. Due to the portability of the set-up it is possible to use the device in the biophotonics laboratory of the Integrated Research and Treatment Centre for Sepsis and Sepsis Sequences (CSCC), the University Hospital or in the cell culture laboratory of the Abbe Center of Photonics, thus considerably expanding the spectrum of the Leibniz IPHT's work so far possible. This infrastructural networking between photonics and medicine will strengthen the application for large-scale interdisciplinary research projects. The planned infrastructure measure will make a significant contribution to further expanding and maintaining Leibniz IPHT's leading position in the scientifically and economically significant and sustainable field of biophotonics.

Project duration: 01.08.2015 to 31.07.2018 

The project is financed by the Free State of Thuringia under the number 2015 FOR 0001 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 Research project SpectroInf

New spectroscopy-based methods for the characterization of infections and sepsis as well as the causative pathogen.

The funded infrastructure enables the Leibniz IPHT to investigate innovative biophotonic solutions for urgent medical questions, in particular for the diagnosis of infectious diseases and for the elucidation of pathogenesis mechanisms of infections that are difficult to treat, and to test them in initial research projects on biological and medical real samples. Within the framework of the project, the technological basis of the Leibniz IPHT is to be extended by special Raman and fluorescence technologies, but also by devices for the cultivation of biological samples, in order to develop new methods for the spectroscopic characterization of physiological interactions in infections. These new methods will shed light on the pathogenesis of difficult-to-treat chronic infections by characterizing the intracellular pathogen and rapidly recognizing the effect of antibiotics in order to identify resistant pathogens within a short period of time, but also to provide insights into the immune response to contact with microbial pathogens and to understand why patients develop sepsis. 

Project duration: 03.02.2017 to 31.03.2019

The project is financed by the Free State of Thuringia under the number 2016 FGI 0010 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 Research project In-SpekT

In-SpekT - In-vivo spectroscopy for clinical transfer

A current research focus at Leibniz IPHT is the development of highly compact fiber-based probe concepts for the clinical in vivo application of Raman spectroscopy. The project aims to purchase spectrometers and lasers specifically for clinical studies in the field of biophotonic spectroscopy.

Duration: February 2017 - March 2019

The project is financed by the Free State of Thuringia under the number 2016 FGI 0011 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 Innovation Certificate A - "Leibniz Centre for Photonics in Infection Research (LPI)"

Innovation Certificate A - Preparation, concretisation and detailed elaboration of the application "Leibniz Centre for Photonics in Infection Research (LPI)" as part of the national roadmap competition for research infrastructures of the BMBF.

The project comprises work on the preparation, concretisation and detailed elaboration of the application "Leibniz Centre for Photonics in Infection Research (LPI)" within the framework of the national roadmap competition for research infrastructures of the BMBF, which is currently being evaluated over several years by the project management agency DLR and the German Science Council.

The Leibniz Centre for Photonics in Infection Research is to establish itself as a user-open photonic centre that researches and develops fundamentally new solutions for the diagnosis, monitoring and experimental therapy of infections and puts them into routine use.

The project is financed by the Free State of Thuringia under the number 2016 IVN 0112 and co-financed by the European Union within the framework of the European Regional Development Fund (ERDF).

 Research project ASTEROID

In the project "Continuous monitoring and automatic control of pharmaceutical processes, based on in-process measurement data and correlation models, using measurement systems coupled with process control at e.g. fluid bed granulation" (Asteroid), the research and development of Raman spectroscopic methods based on imaging and fiber optic concepts for inline process control and monitoring in fluid bed granulators for the pharmaceutical industry is in focus, whereby chemical information about the process is obtained.

In this context, technical parameters/measuring conditions such as spectral resolution, laser excitation wavelength, integration time as well as the concentration dependence, distribution and detection limit of the constituents have to be investigated on model samples outside the fluid bed granulator. The investigated specific parameters are used as a guidepost for the required device specification, on the basis of which a technical concept is created, which is optimized for the problem.

Within the framework of the research project, two concepts will be pursued. In cooperation with the partners, the functional patterns will be integrated into a fluid bed granulator and evaluated.

The project is financed by the Free State of Thuringia under the number 2016 FE 9054 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).

 Research project FEMAGO

The fetal magnetocadiogram (fMKG) is an alternative to conventional prenatal monitoring methods. It has the advantage over fetal ECG that it is non-invasive and can be used in all phases of the second half of pregnancy. Currently common fMKG devices use SQUID as sensors and require magnetically shielded measuring chambers to achieve the necessary measuring resolution. Both of these factors hinder the further spread of the fMKG method. The project aims to overcome these obstacles. Optically pumped magnetometers (OPM) are qualified for the fMKG measurement. This qualification includes the operating mode of the OPM, its integration as arrays using MEMS methods and pumping via adapted microoptics. For the suppression of interference fields (from the heart of the mother and from the environment) it is planned to use the powers of the integrated OPM for the integration of adapted reference sensors, to use the signals of several OPM channels for the recording of the fMKG and a mother ECG. The parallel processing of all this information via software routines should open the way to unshielded measurement.

The quality of the fMKG measurements with this novel measuring system shall be demonstrated by the real recording of fMKG, also in comparison with an established SQUID measuring system.

The project is financed by the Free State of Thuringia under the number 2017 FE 9128 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).

 Research project FEST

The aim of the proposed joint project is to develop a new technology for the production of textile solar cells (DSCs), which serve the mobile power supply from renewable energies. The solar fabrics can be integrated into clothing ("Smart Textiles"), for example, and should be stable against the high mechanical stresses and environmental influences that occur, for example, when a garment is worn and washed. DSC-based solar fabrics are designed to meet the most important requirements for a portable energy source: they are lightweight, mechanically stable and yet flexible. In contrast to conventional silicon solar cells, their production is much simpler and more cost-effective since no vacuum coatings with toxic and explosive gases are required.

The project is financed by the Free State of Thuringia under the number 2016 FE 9028 and co-financed by the European Union within the framework of the European Regional Development Fund (ERDF).

 Research project Hybridglas-SLA

 

The aim of the project is the development of a new and innovative additive technology for the production of complex optical components from quartz glass. The process is based on stereolithography (SLA), in which UV-curing resins are selectively exposed to laser radiation and three-dimensional shaped bodies are built up layer by layer. The hybrid SLA process consists of a two-stage SLA layer process in which modified glass pastes are applied in thin layers and then a second component is added with a print head. The glass pastes consist of a finely dispersed solid (SiO2) and a photosensitive binder and are specially developed for this process. The simultaneous processing of differently doped pastes should enable the construction of three-dimensionally structured components with variable geometry and composition. The produced components are thermally debinded and glazed under active gas atmosphere in a special newly developed gas pressure sintering furnace. After a surface finish, the resulting preforms are to be warped into structured optical fibers, which is an absolute novelty. In addition, optical components are also to be manufactured as examples.

Duration: January 2019 - December 2020

The project is supported by the Free State of Thuringia under the number 2018 FE 9100 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF). 

 Research project Rati

Supported by the Free State of Thuringia with funds from the European Social Fund.

At Leibniz IPHT, the research group "Novel Preparation Technologies for Laser Active Special Preforms and Fibers" (RATI) will carry out fundamental investigations of low-damping, homogeneously doped and large-volume laser active materials based on quartz glass (Al-doped & Al-Tm-encoded) for use in microstructured special fibers. The basis of the planned research work for novel dopants to extend the functionality is the application of established technologies and the fiber technology center in Jena.

Duration: April 2019 - March 2022

Support code: 2018 FGR 0096

Supported by the Free State of Thuringia with funds from the European Social Fund.

 Research project BIADIFA

The research group "Biophotonic analytics and diagnostics using hollow core fibres" (BIADIFA) aims to develop novel optical fibres for the use of innovative solutions in analytics, diagnostics, monitoring and therapy for medical applications and in the field of environmental monitoring. 

Fiber sensor technologies play a key role here due to their extreme flexibility and miniaturization. The aim of this project is to make a significant contribution to the technological progress of photonic technologies as innovative tools in the fields of medicine, health and environmental analysis.

Support code: 2016 FGR 0051

Supported by the Free State of Thuringia with funds from the European Social Fund.

 Research team FaserForLaser

Supported by the Free State of Thuringia with funds from the European Social Fund.

The overall project "Fiber Technology for Researching the Power Limits of Laser Fibers" aims to investigate limiting effects of fiber power scaling for laser systems with excellent beam quality through fundamental investigations. The basis for this is the cooperation between the Leibniz IPHT Jena and the Fraunhofer IOF Jena, which has been proven over many years and whose competencies complement each other excellently in the subject matter applied for here. The synergy of the two subprojects will make it possible to effectively advance this research.

One focus of Leibniz IPHT's research activities will be technological investigations into the realization of thulium- and holmium-doped laser fibers using gas phase doping to open up the spectral range around 2 µm. Gas phase doping is the method of choice for power scaling (cw & pulse power) using large fiber cores (LMA concept) with extremely homogeneous dopant distribution. In addition, concentration ranges of codotands (Al) can be developed, which are decisive for a high energy efficiency of powerful Tm-based fiber lasers (cross-relaxation effects). 

Furthermore, coding with Ce is also to be done via the gas phase in order to suppress photo-darkening (PD) effects in Yb and Tm- doped fibers, which are regarded as a major cause of mode instabilities (MI). From this connection (PD & MI) arises, among other things, the necessity and opportunity for close cooperation with the research group of the IOF in order to gain new scientific knowledge on performance scaling.

Another focus of the research group is the investigation of new photosensitive fibers for the fiber-integrated realization of resonator mirrors.

The shift of the wavelength of fiber lasers into the eye-safe range by 2 µm opens up new fields for applications in medical technology or material processing (e.g. polymer surfaces) in addition to the increase of the mode instability threshold to be investigated. However, this requires a wavelength scalability (tunability) for addressing specific wavelengths around 2 µm. The concept of step-chirped gratings as variably addressable resonators, which has already been successfully applied in Yb-doped fiber lasers, is to be researched here and transferred to larger wavelengths for power scaling.

The joint activities of the research groups also serve to support the work on setting up the fiber technology center on the Beutenberg campus.

Funding code: 2015 FGR 0108

 Research project FBS

With the project "Fiber-based biosensor technology (FBS) - an innovative approach for biophotonics", investments are to be made in order to significantly expand the existing infrastructure at the Leibniz IPHT in the research area of fiber optics and thus to sustainably open up highly topical and new research fields in the fields of medicine or biotechnology. In line with the strategic orientation of the Leibniz IPHT to research and technologically develop new approaches in medicine and the life and environmental sciences, the unique properties of optical fibres are to be used for new solutions in medicine and biophotonics in order to establish Thuringia as a leading location for medical and life science sensor concepts and products.

The project is financed by the Free State of Thuringia under the number 2015 FGI 0011 and co-financed by the European Union within the framework of the European Regional Development Fund (ERDF).

 Research project FLUISENS

In the project, a chemically highly selective and sensitive, miniaturized Raman module for the decentralized inline analysis of biomolecules in a fluidic system is to be investigated in order to meet the demand for mobile, decentralized analysis and diagnostic procedures in medicine, pharmacy, the environment and the food industry.

The project is financed by the Free State of Thuringia under the number 2015 FE 9012 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).

 Research project InphoDeG

The aim of the research project "Research and Production of Highly Sensitive Photonic Detectors for Optical Health Technologies" (InphoDeG) is to expand the infrastructure for the simulation, production technologies and metrological characterization of photonic detectors. In order to successfully implement the focus on optical health technologies at the IPHT, it is necessary to expand and maintain a broad range of interlocking complementary technologies, which enable the technical implementation of different sensor concepts, e.g. using functionalized surfaces and quantum-based detection mechanisms, up to their technical integration into innovative imaging and highly sensitive measurement systems for medical application scenarios.

Here, the scientists essentially link three different working directions synergetically with each other:

  1. Innovative sensor, light collector and light source concepts based on nano - and microstructured metal and semiconductor structures, 
  2. Molecular light detection (nanoscopy), high-resolution far-field microscopy and hyperspectral imaging,
  3. Radiation detection in a very wide frequency range from X-rays to VIS to the far infrared.

This interdisciplinary approach leads to innovative detection approaches in the field of optical health technologies, such as spatially and temporally high-resolution spectroscopic methods for the investigation of life processes.

The project is supported by the Free State of Thuringia under the number 2015 FGI 0008 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF).

 "Innovationsgutschein"

"Innovationsgutschein" for the preparation of an R&D cooperation project with the topic: "Active and passive textile cooling systems based on nanoscale semiconductor materials by using the thermoelectric effect".

The "Innovationsgutschein" serves to prepare an FTI (Fast Track to Innovation) cooperation project for submission to the EU as part of Horizon 2020. 

The work includes the development of the concrete task and the strategy of the project for the development of textile-based thermoelectric cooling systems for integration in clothing and for industrial applications, measures for the acquisition of the necessary cooperation partners as well as the execution of patent studies, literature searches and market analyses.

Project duration: 24.6.2016 to 15.10.2016

The project is supported by the Free State of Thuringia under the number 2016 IVN 0063 and co-financed by European Union funds within the framework of the European Regional Development Fund (ERDF).

 Research project PlasmidChip

 

Collaborative project: "Development of a modular multiplex detection system for plasmid-based antibiotic resistance monitoring (PbR - plasmid-based resistance detection)".

Subproject: "Development of a multiplex detection system of resistance genes by separation of natural plasmids from complex samples and subsequent detection of plasmid antibiotic resistance genes on a plasmonic microarray chip (PlasmidChip)".

Microbial antibiotic resistance is an increasing worldwide problem for patient care. The resistance is spread via independently replicating mobile plasmids, which are even exchanged between the bacteria across species. The main focus of the available monitoring systems is on hospitals. Natural plasmids, which are mainly exchanged between the pathogens in the environment, are currently not depicted.

The joint project therefore aims to develop a plasmid-based antibiotic resistance monitoring system. The aim is to use an innovative plasmid isolation method that is integrated into a microfluidic chip. Resistance testing will then be carried out, also integrated on the microfluidic chip, using a highly innovative and label-free plasmonic method. The signals will be read using imaging spectrometry. The joint project will benefit from the close integration of the experts and the coordination by the industrial partner integrating the entire system. 

The project is supported by the Free State of Thuringia under the number 2018 FE 9039 and co-financed by funds of the European Union within the framework of the European Regional Development Fund (ERDF). 

Duration: March 2019 - February 2022

Project partner:

SIOS Meßtechnik GmbH, Ilmenau (Project Coordinator)

Mildendo Ltd., Jena

University Hospital Jena, Institute for Infection Medicine and Hospital Hygiene

 Research project MultiHoloDiag

Supported by the Free State of Thuringia with funds from the European Social Fund.

The aim of the "MultiHoloDiag" research group is to investigate multiparameter measurements of the interaction of biomolecules with optical-holographic methods for use in medical diagnostics. Detection units based on holographic methods are used, which are also technologically suitable for on-site diagnostic use. The group develops solutions for preanalytics and for the label-free, highly sensitive detection of single molecule layers. The systems are developed and tested using clinically relevant samples.

Funding code: 2018 FGR 0095

Duration: January 2019 - December 2021

Current EU Projects

 ACTPHAST

ACTPHAST - Access Center for Photonics Innovation Solutions and Technology Support

ACTPHAST is a unique "one-stop-shop" European access centre for photonics innovation solutions and technology support (Access CenTre for PHotonics innovAtion Solutions and Technology support). ACTPHAST supports and accelerates the innovation capacity of European SMEs by providing them with direct access to the expertise and state-of-the-art facilities of Europe's leading photonics research centres, enabling companies to exploit the tremendous commercial potential of applied photonics.
Coordinator: Vrije Universiteit Brussels, Belgium

Project movie

 BiophotonicsPlus

BiophotonicsPlus: "Photonic appliances for life sciences and health”

BiophotonicsPlus is a transnational call for research and development project proposals on ‘photonic appliances for life sciences and health’, primarily aiming at the stimulation and support of innovative R&D projects which will translate existing biophotonic technologies and methods into appliances and put them into clinical, medical or industrial practice.

Projects funded via BiophotonicsPlus with Leibniz IPHT being either coordinator or partner:

FastFibreSim
High-resolution Microscopy for Living Cell Diagnostics: In the project Fast Life Cell Structured Illumination Microscopy (FastFibreSIM), a transnational consortium (Germany, UK) aims to improve the imaging speed of the SIM microscopy significantly to allow live cell imaging. This new microscope will enable life cell imaging of fast processes under physiological conditions. The project is running under the FP7 ERANET BiophotonicsPlus on "Photonic appliances for life sciences and health".
PhotoSkin
Optical needle sensors for therapy monitoring of inflammatory skin diseases to prevent recidives (PhotoSkin)
The PhotoSkin sensor will provide an entirely new access to clinically relevant information based on the three-dimensional lipid structure within psoriatic skin. Coordinated by Leibniz IPHT, the project combines a range of transnational complementary competences and experiences in innovative high-tech companies (Z-light Ltd/Latvia, Elfi-Tech Ltd/Israel and TOPTICA Photonics AG/Germany), and a research-intensive hospital (Charité, Germany).
Real-MFM
Real-time multispectral flourescence spectroscopy using energy resolved single-photon detector arrays (Real-MFM)
The radical approach proposed here is to use a photon detector which discriminates single photons in terms of both time and energy. This technique demands performance in detection which closely approaches fundamental physical limits. 

 CanDo

CanDo: Chip-sized Analysis Laboratory Used in the Early Detection of Cancer

The Leibniz Institute of Photonic Technology (IPHT) researches a miniature laboratory used in the early detection of pancreatic cancer together with nine European partners as part of the EU project CanDo, among them three companies (Bayer, Imec and Gilupi) as well as seven research organisations and universities.
Coordinator: University of Valencia, Spain

 Cost Action Raman4Clinics

Raman4Clinics pools European expertise to step forward in the field of novel, label-free and rapid technologies based on a wide variety of Raman spectroscopies for the clinical diagnostics of body fluids, bacteria, cells and tissues. International interdisciplinary networking opportunities are offered between scientists within biophotonics, chemometricians and physicians/clinicians. Currently, the network has more than 150 members out of 26 countries.
Coordinator: Leibniz IPHT, Germany

 FINESSE

Marie Skłodowska-Curie Innovative Training Network: FIbre NErve Systems for Sensing (FINESSE)

The objective behind FINESSE (FIbre NErvous Sensing SystEms) is to mimic the nervous system of living bodies by turning man-made and natural structures into objects that are sensitive to external stimuli owing to advanced distributed fibre-optic sensor technology, with the objective to either give early warning in case of possible danger or occurrence of damage, or to optimise the operation of the structure to allow for a sustainable use of natural resources and assets. 26 European universities, research centers and industrial partners have teamed up to set up this Innovative Training Network, with the common objective of educating and training 15 Early Stage Researchers (ESRs) in the development of a set of disruptive new optical ‘artificial nervous systems’ and to boost the industrial uptake of these sensors by technology transfer from academic research to the European optical fibre sensor industry.
Coordinator: École polytechnique fédérale de Lausanne – EPFL

 HemoSpec

The EU-project HemoSpec develops an innovative photonic device for early, fast and reliable medical diagnosis of sepsis using only a minimal amount of a patient’s blood. The project involves two hospitals, the University Hospital in Athens and Germany’s Centre for Sepsis Control and Care (CSCC), as well as four companies: France’s Horiba Scientific; biomedical software company, Bmd (Portugal); ViroGates, an international Biotech company (Denmark); and biomedical instrument manufacturer, Data Med (Italy). HemoSpec combines three complementary biophotonic technologies into one device: automated microfluidic sample handling with integrated holographic blood count; simultaneous multiplex fluorescence biomarker sensing; and detailed Raman spectroscopic leukocyte characterisation.
Coordinator: Leibniz IPHT Jena, Germany

Project movie

 LaserLab Europe

LaserLab Europe - The Integrated Initiative of European Laser Research Infrastructures

Under Horizon2020, Laserlab-Europe has entered a new phase of its successful cooperation: the Consortium now brings together 33 leading organisations in laser-based inter-disciplinary research from 16 countries. Together with associate partners, Laserlab covers the majority of European member states. 22 facilities offer access to their labs for research teams from Europe and beyond.

 LUNGCARD

LungCARD

Chemotherapy is the standard care for the treatment of non-small cell lung carcinoma (NSCLC) patients, however most of non-small cell lung cancer tumours are not sensitive to this treatment. As an alternative to chemoterapy, target therapy with gefitinib (epidermal growth factor receptor-tyrosine kinase inhibitor) has been used in clinical practice in patients with tumours harbouring mutations in EGFR gene, improving their treatment effectiveness. The LungCARD project has developed a lab-on-a-chip device for the detection of EGFR mutations on circulating tumor cells from Non-Small Cell lung cancer (NSCLC) patients via gold-nanoparticle (AuNPs) based detection.

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 MIB

MIB - Multi-modal, endoscopic biophotonic Imaging of bladder cancer for point-of-care diagnosis

Early Detection of Bladder Cancer: From 2016 - 2020, IPHT researches a novel endoscope for the quick diagnosis of bladder cancer as part of the 6-million-EU project MIB. Medical doctors will be able to detect whether and how deep cancer tissue has penetrated the inner wall of the bladder during a routine check-up without having to take a sample. The goal is to improve the treatment of patients and relieve the strain on the health care system.
Coordinator: Technical University of Denmark

 MOON

The rising life expectancy of EU citizens is creating a dramatic increase in age-related degenerative diseases and associated healthcare costs. The MOON Project (Multi-modal Optical Diagnostics for Ocular and Neurodegenerative Disease) meets this societal challenge by applying photonics to diagnose age-related diseases of the eye and central nervous system. Consistent with the Photonics KET 2016 Work Program, MOON will design and build a multiband, multimodal and functional imaging platform combining label-free molecularly sensitive Raman spectroscopy with high speed and high-resolution Optical Coherence Tomography (OCT), for in-depth diagnostics of ocular and neurodegenerative diseases.
Coordinator: Technical University of Vienna

 Cost Action PerspectH2O

COST Action PerspectH2O

PERSPECT-H2O is a 4-years COST Action integrating leading European groups and national research centers of more than 22 countries, focusing on a central theme of contemporary research in homogeneous photocatalysis and integration of supramolecular photocatalysts towards the construction of functional materials.
Coordinator: Leibniz IPHT, Germany

 Photonics4Life

Photonics4Life - Network of Excellence for Biophotonics

As a Network of Excellence, Photonics4Life is composed of partners standing on the forefront of Biophotonics research and covering together the broadness of fields. The partners work towards a durable integration, provide a critical mass that will act as a nucleus for integrated fundamental and applied Biophotonics research across Europe and reach out to the international scene.
Coordinator: Leibniz IPHT , Germany

 PROBE

Dr. Stephen Warren-Smith from the Centre for Nanoscale BioPhotonics (CNBP), Adelaide/Australia is researching for two years at the Leibniz Institute of Photonic Technology (Leibniz IPHT). The Marie Skłodowska-Curie action program is supporting his research stay. The research of Dr. Warren-Smith focuses on the development of tiny fiber sensors for biomedical applications. These sensors will be adjusted to the requirements of the measurement of specific biological processes by improving the fiber design as well as the manufacturing operations. That way, innovative optical tools will be provided for life science as well as medical diagnostics.
Coordinator: Leibniz IPHT, Germany

 RA Detect

RA Detect: One Platform- Multiple biomarker detection of Rheumatoid Arthritis

In this EU-Indian project we develop an on-site detection diagnostic system that identifies multiple markers of rheumatoid arthritis. Rheumatoid arthritis is a complex, chronic autoimmune disorder causing chronic disability worldwide and prevalent in the ageing population.

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 SMARTER-SI

SMARTER-SI: Smarter Access to Manufacturing for Systems Integration

SMARTER-SI is an Innovation Action that receives funding from the European Commission's Horizon 2020 Programme under Grant Agreement No. 644596, and the Swiss State Secretariat for Education, Research and Innovation (SERI). In order to provide access to manufacturing capabilities for SMEs, several European Research and Technology organisations (RTOs) joined efforts, among them Leibniz IPHT.

The core of the initiative is the networks of competence centres, usually research technology organisations (RTOs) or technology transfer-oriented university institutes who cluster a wide spectrum of technical and application knowledge to support innovation. Inspired by the Strategic Research Agenda of EPoSS, SMARTER-SI aims to develop an RTO Community Foundry Model (CFM) that will accelerate a wider deployment of SSI with greater access to design, manufacturing capabilities for prototyping, early validation and first production for SMEs to exploit in niche markets.

Project video
https://www.youtube.com/watch?v=OyGW9s4eCNI&feature=youtu.be

 TRACE

TRACE - Tracking and Assessing the Risk from Antibiotic Resistant Genes using Chip Technology in Surface Water Ecosystems

Given the serious public health threat posed by antimicrobial resistance, it is important to investigate the potential role of surface water in amplifying the emergence and spread of antimicrobial resistance and to assess the potential associated risk to human health. Research into the occurrence, fate, effect, and risk associated with the presence of antimicrobial resistant bacteria in such environments and the impact on human health is urgently needed for informed policy decisions.
TRACE will develop detection technologies that allow for a simpler on-site detection of antibiotic resistance, thereby enabling a much higher throughput and faster result-to-user turnaround. TRACE is a water research project funded by the first joint call of the Water Joint Programming Initiative (JPI).

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 WaterChip

WaterChip  - DNA Biochip for on-site water pathogen detection including viablility and antibiotic resistance testing

Globally, nearly 6,000 children die each day due to water-related illnesses. The WaterChip  consortium combines academic and industry partners with expertise in molecular biology (ILS Ahmedabad, India), bioanalytical services (Food GmbH, Germany), pathogen detection technology development (IPHT, Germany) and on-site detection technology (ABC Genomics, India), in order to realize a great innovative solution: Rapid (in less than 1-hr) detection platforms covering waterborne pathogens, their indicators, and associated sources of antibiotic resistance bacteria on a single chip.

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 WISC

WISC - Window Integrated Solar Collector

New INDIGO Partnership Programme on Energy Research- New INDIGO Initiative for the Development and Integration of India and European research. Today’s trend of increasing window areas especially in public and office buildings results in the problem of excess heat collection inside (greenhouse effect), which leads to higher energy consumption in air conditioning and thus for higher costs. In the EU-Indian project WISC we propose a novel principle of separating the heat (IR part) from the visible light and use it for energy generation, without scarifying parts of the window areas or otherwise reduce the visible illumination. This groundbreaking idea will be realized by a functionalized window including plasmonic nanoparticles, a waveguide arrangement, and thermoelectric conversion.

Finished Projects

 Csionglass

As part of the European Commission’s Marie Skłodowska Curie research fellowship program, Dr. Michael Vetter is researching a new method of manufacturing crystalline silicon thin-film solar cells on glass at IPHT for the next two years.

Coordinator: IPHT Jena, Germany

Click here for Project Highlights

 E-SQUID

E-SQUID (Development of SQUID-based multiplexers for lage Infrared-to-X-ray imaging detector arrays in astronomical research from space)

Recently, research in astrophysics has yielded amazing new insight in the origin, evolution and structure of the Universe, and fundamental processes governing this highly dynamical system.

Koordinator: HELSINGIN YLIOPISTO, Finland

 FIBLYS

FIBLYS - Building an Analyzing Focused Ion Beam for Nanotechnology
The project FIBLYS aims at developing an innovative nanostructuring, nanomanipulation and nanoanalysis instrument: a hybrid scanning probe (SPM) and dual beam focussed ion beam (FIB) instrument (including scanning electron microscopy (SEM) capabilities).

Coordinator: Leibniz IPHT Germany

 HIGH EF

HIGH EF - Large grained, low stress multi-crystalline silicon thin film solar cells on glass
HIGH-EF will provide the silicon thin film photovoltaic (PV) industry with a unique process allowing for high solar cell efficiencies (potential for >10%) by large, low defective grains and low stress levels in the material at competitive production costs.

Coordinator: Leibniz IPHT Germany

 Nano3T

Nano3T - Biofunctionalized metal and magnetic nanoparticles for targeted tumour therapy
The cause of diseases is often unknown, but their origin can frequently be found at the biomolecular and cellular level situated on nm-scale. Early diagnostics combined with early intervention on that nanoscale is one of the holy grail of modern medicine.

Coordinator: Interuniversity Micro-electronics Centrum (IMEC), Leuven, Belgium

 NanoPV

NanoPV - Nanomaterials and nanotechnology for advanced photovoltaics
The NanoPV project aims at making a breakthrough step-change in photovoltaics by the removal of a set of bottlenecks which have been identified to block the application of nanostructures for high-efficiency, low-cost solar cells.

Coordinator: STIFTELSEN SINTEF, Trontheim, Norway

 RODSOL

RODSOL - All-inorganic nano-rod based thin-film solarcells
Thin film solar cells, based on non-toxic, abundant and air-stable silicon (Si) will probably, based on forecasts, dominate the photovoltaic market in the future and thus replace bulk Si from its leading position.

Coordinator: Leibniz IPHT, Germany

 S-Pulse

S-Pulse - Shrink-Path of Ultra-Low Power Superconducting Electronics
The proposed Support Action S-PULSE aims to prepare Superconducting Electronics (SE) for the technology generation beyond the CMOS scaling limits ("beyond CMOS").

Coordinator: Leibniz IPHT, Germany

 SINAPS

SINAPS - Semiconducting Nanowire Platform for Autonomous Sensors
The aim of the SiNAPS project is to develop standalone “dust”-sized chemical sensing platforms that harvest energy from ambient electromagnetic radiation (light) and will enable miniaturisation below the current mm3 barrier.

Coordinator: UNIVERSITY COLLEGE CORK, Irland

 SOLID

SOLID - Solid State Systems for Quantum Information Processing
The SOLID concept is to develop small solid-state hybrid systems capable of performing elementary processing and communication of quantum information. This involves design, fabrication and investigation of combinations of qubits, oscillators, cavities, and transmission lines, creating hybrid devices interfacing different types of qubits for quantum data storage, qubit interconversion, and communication.

Coordinator: CHALMERS TEKNISKA HOEGSKOLA AB, Sweden

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