Real-time molecular imaging of near-surface tissue using Raman spectroscopy
Current medical imaging techniques mostly provide information based on morphological or anatomic differences of the tissue, disregarding the underlying molecular composition. Molecular-sensitive methods, such as Raman spectroscopy, have shown significant potential for clinical in vivo diagnostics by providing the intrinsic molecular fingerprint of a sample label-free, without contact, and non-destructive. The advantage is that the information can be used to detect and potentially delineate cancer from healthy tissues. However, current implementations of fiber optic probe-based Raman systems remain far behind the technological possibilities the method can offer.