Achieving a new generation of enhanced sensors requires the development of structures that result from the fusion of different concepts and effects. In this paper, we combine a special strain sensing structure with an optical sensitivity magnification, through harmonics of the Vernier effect. The recently demonstrated harmonics of the Vernier effect result from increasing the optical path length (OPL) of one of two interferometers by multiple times the OPL of the other interferometer. The effect generates higher magnification factors, proportional to the order of the harmonics. The sensing structure is demonstrated for strain and temperature discrimination, allowing compensation for temperature fluctuations. We explore the complex case of the optical Vernier effect in series, where both interferometers are used as sensing interferometers (no reference interferometer is used). Our results also suggest that the magnification enhancement provided by harmonics of the Vernier effect for a configuration in series is the same as for a configuration in parallel: the magnification factor increases proportionally to the order of the harmonics.